Yep. Blowouts hurt.
Bob Stoops never fully recovered from 19-55 against USC in the 2004 (season) NCG. He wasn't "Big Game Bob" anymore.
He started the season 2-3, with losses to TCU, UCLA, and Texas (12-45, worst-ever loss to Texas, IIRC), and finished 8-4. Lost the next 3 BCS bowls he was in, including the 2008 (season) NCG vs. Florida.