So to 'think out loud' for Florida, I know Huey Richardson had more sacks than Jevon Kearse, but playing this game, it would be cooler to have Kearse getting a sack, so I could include him instead.
Same with defensive back - I know Keiwan Ratliff had a lot of INTs, and he was an All-American type player, but Lito Sheppard was better or cooler or whatever, so I could include him instead. Lots of freedom here.
Ohio St RB is interesting. You have Griffin and George and Wells and Elliott, but you also have 2 QBs in the top 10 of rushing yards. If you want Barrett or Miller at QB for the all-time Buckeyes, and you want their rushing abilities, you have to drop a RB. And if you're partial to a guy like Pete Johnson, who racked up TDs as a short-yardage guy, you could include him instead of one of the top guys, no problem.
If I'm creating ND's team, I want Rocket Ismail's 22 yards per catch and 7.7 yards per rush, BUT his relatively few receptions and carries means that he's not going to have many play cards. The few he will have will be explosive, but a Tim Brown is going to have nearly double the pass play cards as Ismail and a RB like Alan Pinkett's carries dwarfed Ismail's. While Pinkett would have probably 7-8 run cards, Ismail may have just one. So getting deep into it, you want a sliding scale of effectiveness and volume.