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US in danger of not advancing now

I infer none of them work with this new stuff.

Cychlorphine (N-Propionitrile chlorphine) is a synthetic opioid chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the USA.^[1] It has been found in Canada as of September 2025.^[2] It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine has been published.^[3][4][5] It is not a structural analog of morphine, despite the similar name. Instead, it is an orphine.^[6]

Fentanyl is a highly potent synthetic opioid of the piperidine family, used primarily as pain medication. It is 50 to 100 times more potent than morphine. Its primary clinical use is in pain management for cancer patients and those recovering from surgery.^[17][18] Fentanyl is also used as a sedative for intubated patients.^[19] Fentanyl has a short duration of action. Fentanyl works by activating μ-opioid receptors.^[15] Brand names include Actiq, Duragesic, and Sublimaze, among others.^[20]

Well, that's great news.  Steel yourselves for the next wave of deaths.

A coworker of mine was working on an artificial sweetner many times sweeter than current (at that time).  The concept was to facilitate safety testing.  Since you'd only need a tiny amount, the potential exposure would be much lower than say saccharin.  It made a lot of sense, to me, and he succeeded, in part, he had some compounds 20,000 X sweeter than saccharin.  However,  they had a lingering taste that was rather unpleasant.  

He made these in his lab and  then tasted them himself before putting them into blind tasting tests.

That was back in the day when we had an "artificial" fat with no calories coming out.  For various reasons it was later abandoned, but was fascinating, to me.

I was musing about man made structures that will persist the longest in life.  Pyramids would be a possible.  The Stone Mountain carving is larger (in relief) than Rushmore, but Crazy Horse is crazy large.