Well the play cards are based on the player's yards per rush or catch, so that works out okay. The QB completion percentages were pretty bad back in the day, but their defensive numbers may help out a lot.
'60 Iowa seems to have had a 1a and 1b at RB, and the 1b guy had a 7.4 yards per rush average. That'll work out great.
The QBs had around a 40% completion percentage, so obviously (and realistically), you'd run the ball a ton, only passing as a change of pace to get the defense to stop keying on your inside and outside runs.