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Both wins and losses - the "holy sh*t" outcomes you wouldn't have envisioned going either way.
I'm limiting it to 1970 - two platoon football, integrated, etc.

And not just random games - I'm looking for ranked vs ranked games that everyone thought would be competitive, but turned into ugly curb-stomps.....

Florida
1982 - #20 Florida vs #3 Georgia - LOST 44-0

1990 - #9 Florida @ #5 Tennessee - LOST 45-3
1990 - #15 Florida vs #4 Auburn - WON 48-7

1993 - #8 Florida vs #3 West Virginia (Sugar Bowl) - WON 41-7

1995 - #2 Florida vs #1 Nebraska (Fiesta Bowl) - LOST 62-24

1996 - #1 Florida vs #12 LSU - WON 56-13
1996 - #1 Florida vs #16 Auburn - WON 51-10
1996 - #3 Florida vs #1 FSU (Sugar Bowl) - WON 52-20

2001 - #2 Florida vs #21 Miss State - WON 52-0
2001 - #4 Florida @ #14 S.Carolina (game I attended) - WON 54-17
2001 - #5 Florida vs #6 Maryland (Orange Bowl) - WON 56-23

2002 - #6 Florida vs #1 Miami - LOST 41-16

2006 - #2 Florida vs #1 Ohio St (NCG) - WON 41-14

2008 - #2 Florida @ #24 S.Carolina - WON 56-6

2015 - #19 Florida vs #17 Michigan (Citrus Bowl) - LOST 41-7

2016 - #15 Florida vs #1 Alabama (SECCG) - LOST 54-16

There was a year in the 90s where Florida beat LSU 58-3 in Death Valley.  A decade later, now even, that's a holy sh*t score....but back then, LSU stunk.  So who cares, right?

That one year Miami beat ND like 58-7.  Ohhh, it's Notre Daaaaaame.  So?  They stunk that year.  The Canes thrashing #3 Texas in the Cotton Bowl in 1990 is much more noteworthy, 30 years after the fact.

I'll go through and post some other school's "wow" games, but everyone should do some of their own.

Michigan
1972 - #8 Michigan @ #18 Tulane - WON 41-7
1977 - #3 Michigan vs #5 Texas A&M - WON 41-3
1977 - #1 Michigan vs #14 Wisconsin - WON 56-0
1985 - #19 Michigan @ #15 S.Carolina - WON 34-3
1990 - #12 Michigan vs #15 Ole Miss (Gator Bowl) - WON 35-3
2003 - #5 Michigan vs #15 Notre Dame - WON 38-0
2015 - #18 Michigan vs #13 Northwestern - WON 38-0
2015 - #12 Michigan vs #8 Ohio State - LOST 42-13
2015 - #17 Michigan vs #19 Florida (Citrus Bowl) - WON 41-7
2017 - #19 Michigan @ #2 Penn State - LOST 42-13

Both were in the top 15 when MSU lost 48-3 at OSU last year.

My guess for win was going to be 1998 against a top 10 Notre Dame team.  MSU scored on 5 of their first 6 possessions, plus a Julian Peterson pick 6 to go up 42-3 with about 10 minutes left before halftime, but ND outscored MSU 20-3 over the remaining 40 game minutes.  I'll still say 22 points is their biggest MOV over a ranked team in a long time.

I'm just going to go with a few memorable ones...

2004: Purdue 41, Notre Dame 16. This was Orton's senior year, and Purdue just hounded the hell out of Brady Quinn all day long. Quinn was a good QB when he had protection, but tended to fold under pressure, and Purdue brought the heat. The memorable point was Purdue backed up on their own 3, Orton throws a fade to Taylor Stubblefield on the right sideline (whose defender falls down during the catch) and rolls 97 yards for the TD. It was just one of those days for ND.

2008: Purdue 62, Indiana 10. Joe Tiller's final game, and Curtis Painter's final game. The team wanted to send them out in style, and did so with an utter dismantling of Indiana. This wasn't a "ranked vs ranked" game. In fact, it was two 3-win teams facing off (Purdue improving to 4-8, Indiana finishing 3-9). But it's a rivalry, and even when both teams aren't that good, you still want to destroy your opponent.

2003: Michigan 30, Purdue 3. This was an unexpected beat-down. In 2003 Purdue was quite good, with a solid running game, elite defense, and ranked #10 in the country at 6-1 coming into the game. Purdue was expected to be competitive. I was at a fraternity brother's wedding, and was hanging out in the basement of a church listening to the game on the radio with the groomsmen. We all had such high hopes, and were almost stunned by the way Michigan just bullied us on both sides of the ball all day long. Much like my fraternity brother's marriage, this one wasn't right from the start. 

My first Purdue football game as a student:  1992 home game against Cal.  Cal was coming off a 10-2 season and finishing ranked 8th in the AP poll.  They lost a lot to graduation, but still came in ranked 17th.

Purdue just kicked the stuffing out of them.  Halftime score was 38-3 and they let off the gas in the second half to finish 41-14.  The goal posts were ripped down in celebration.  Much booze was consumed.

That was also one of those games where a rabbit got onto the field and proceeded to run back and forth from end-zone to end-zone.  The rabbit had more yardage than Cal did that day.

Now, it turns out, Cal sucked that year and finished only 4-7, but it was one of those completely unexpected blowouts that this thread was looking for.

Alright, OSU's biggest blowout loss appears to be an 86-0 setback to the Wolverines in 1902. 

The amazing thing about that to me is that the 86-0 win over Ohio State wasn't even among Michigan's top three wins that year.  They beat:

• Michigan State 119-0
• Iowa 107-0 (this was a conference game)
• Albion 88-0

They also shutout Indiana, Notre Dame, Wisconsin, Chicago, and Oberlin.  Case and Minnesota did manage to put points on the board against Fielding Yost's "point-a-minute" squad but not enough to win.  Michigan finished 11-0 outscoring their opponents 644-12.  

The previous year they outscored their opponents 550-0 with the closest game being a 21-0 win in Columbus over the Buckeyes (Hey, at least we did better than their other 10 opponents!)  The following year they outscored their opponents 565-6 with the only points allowed being six points to Minnesota in a 6-6 tie (the Gophers were really good back then).