If we assign "points" to significant plays, I'm going to argue the Wade targeting was the biggest impact on the game.
Wade Targeting - 14 pts. - turned a punt into a 1st down, replacement player called for PI, lead to Clemson's 1st score; replacement player juked by Lawrence on 2nd TD run.
OSU Red Zone Sputtered - 12 pts. - if those 3 field goals were TDs that's 12 points OSU left in the wind.
Clemson's last drive - 8 pts. - Give the Tigers credit, then earned that last TD + conversion.
Roughing the Kicker - 7 pts. - instead of a punt lead to a Clemson TD
Fumble Score - 7 pts. - Okudah's strip that became an incomplete pass took 7 off for OSU.
Dobbins TD scamper - 7 pts.
OSU 4th and 2 TD - 7 pts.
Any other big plays I'm missing?