I was trying to think through best/good option candidates in each conference. Here's what I got:
Big 10 -
Illinois - A program always looking for identity that seemingly never recruits all that well or has buzz.
Other ideas: Maybe NW, which has gone through a weird history of offenses. If it was at its pre 1995 success levels, this would be a given. Instead it became a power downhill team, then an early spread innovator and slipped into a spread that felt as stodgy as people consider the option. Since that offense has been bad for years and Fitz is a defensive coach, why not.
SEC -
Vandy - They need to be weird, though Andy Ludwig got them kinda good at pro style for a second
Other ideas: IF Kentucky hadn't gotten good with the current ground and pound, that would be the pick. Otherwise, you're looking for a team that would sacrifice the highest end ceiling and recruiting for some moments of glory. No one really fits unless Mizzou hits a big ole snag.
Big 12
Kansas: Already bad, get weird
Other ideas: K State. They used to run the option. They've basically always run a kinda single-wingish old-school spread. Not too much of a stretch.
ACC
The pick: Ehhh, it's tricky. I guess Syracuse? Duke and Wake would be options, but both have good coaches doing good things.
Other options: Pitt might want it given their normal identity. Tech might regret leaving it. Boston College has often been running offenses where the alternative can't be so much worse.
Pac-12
Oregon State: This is always the one floated because its the least resourced and its floor is always the lowest.
Other ideas: Cal? A school that is often not very good, bad on offense right now and mostly doesn't recruit well? I could buy it.