For Purdue...
2005 was pretty good. Had Ray Edwards and Rob Ninkovich at DE, with Anthony Spencer as a RS Soph to spell them, along with Brandon Villareal at DT. I don't remember the 2nd DT though, despite looking at the roster, so maybe there was a weak spot there.
2010 probably has to be the top one, though... Ryan Kerrigan (DE), Kawann Short (DT), Bruce Gaston (DT), and Gerald Gooden (DE) were the front four. All except Gooden saw some time on Sundays, with both Kerrigan and Short having long careers in the league. Kerrigan was an absolute terror that year, Short was still younger but very good, Gaston was a freshman but big and strong enough to play day 1, and Gooden certainly got the job done with all the attention being spent on Kerrigan and Short.