To be fair, we packed a LOT into our week in Rome on our honeymoon.
The main event was going to the night Mass with Papa Frankie on Christmas Eve in St. Peter's. The atmosphere was like a super-reverent but high stakes football match. We waited in line with the family of a seminarian from North Dakota (tall English speakers tend to attract other English speakers), and were seated inside the basilica with a bunch of Brazilians.
St. Paul's Outside the Walls was my favorite of the papal basilicas.
We went to the Vatican Museums while there over Christmas 2021. Attendance at the time was capacity limited by COVID. And if the place was that busy while capacity-constrained, I don't want to be within a country mile of there in August with no restrictions on attendance.
Cacio e pepe in Rome was fantastic, and, despite it's simplicity, is something that the Mrs. and I have been utterly unable to replicate back stateside.
We tend to have a fairly loose schedule when we travel. If there are big-ticket events, schedule for that, but we don't want to be tied to an airtight schedule.