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Topic: Coronavirus discussion and Quarantine ideas

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betarhoalphadelta

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15344 on: August 31, 2021, 10:45:21 AM »

How much does all this focus on Florida ignore other states deserving of questions too?
Re: Florida, it gets a lot of spotlight because Badge keeps posting the Florida numbers whereas many of the rest of us don't post our own state numbers any more, and because so many posters are in (or from) Florida that it makes it a hot topic. 


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Take Oregon, one of the most vaccinated states, yet their cases keep rising (see below). Even more newsworthy is how many “breakthrough” cases are occurring across Oregon. 60% of Covid cases at a recent outbreak at the Gateway Assisted Living Facility in Springfield Oregon were breakthrough cases.


Regarding an assisted living facility, I would ABSOLUTELY expect most of their cases to be breakthrough cases, because I would think that almost their entire population of residents are vaccinated.

We know the Pfizer and Moderna vaccines are only 95% effective at avoiding symptomatic illness. Past data suggests the ratio between symptomatic and asymptomatic infection amongst unvaccinated people is about 50/50. Assuming all these residents are symptomatic (not a safe assumption--in an assisted living facility they may do 100% testing once there was an outbreak), if there is a 90% vaccination rate at the facility and literally EVERYONE in the facility had enough exposure to the virus to catch the infection, you can do the math. 5% of vaccinated residents (4.5% of total) would have symptomatic illness, and 50% of the unvaccinated residents (5% of total) would have symptomatic illness. Thus you'd have nearly a 50/50 split between breakthrough and natural infections.


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How much is the CDC’s sudden push for Boosters every 5 to 8 months stemming from a reaction to avoid directly admitting an evidently decreasing effectiveness of the current roster of vaccines that were promoted as our final ticket past Covid? A population thus far only 50 or 60% onboard with getting initially vaccinated is now expected to face Boosters in perpetuity?

I've got some issues with the push for boosters. I'd like to better understand the immunity cycle both for natural infection and for vaccination. How much latent immunity lasts for years in the B cells and T cells, which seem to have "memory" of infection? Is there a difference in the level or duration of that longer term immunity between natural infection and vaccination? I don't really have a good way to answer that, and it appears that the studies on this are all very early-term (because this pandemic is still early term and vaccination less than half the total term). 

I do worry how much of the push for boosters is $$$ from Pfizer and Moderna. Is there enough data to say that the immunity isn't long term to justify it? 

What we do know about other coronaviruses is that immunity may not be infinite. I.e. if you get a common cold from one virus, you may catch that common cold from the same virus two years later. We don't really understand long-term immunity for this coronavirus, though.

That said, what if we learn that the vaccine only grants 8 months or so of immunity, and natural infection only grants 8 months or so of immunity? Is that somehow the fault of the vaccines because they're offering boosters? 

Unless there is strong evidence that the immunity granted by natural infection is significantly stronger or of longer duration than the vaccine, then the vaccine is much more preferable. In fact, even if the immunity granted by natural infection is of longer duration than the vaccine, the vaccine may still be preferable because of how effectively it reduces symptomatic illness, hospitalization, and death. 

longhorn320

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15345 on: August 31, 2021, 11:03:40 AM »
.
That said, what if we learn that the vaccine only grants 8 months or so of immunity, and natural infection only grants 8 months or so of immunity? Is that somehow the fault of the vaccines because they're offering boosters?



Have we learned this or suspect it

I have not seen any actual findings on this
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betarhoalphadelta

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15346 on: August 31, 2021, 01:33:40 PM »
Have we learned this or suspect it

I have not seen any actual findings on this
We don't really know how long either natural or vaccine-derived immunity lasts. We know that antibody numbers decline over time, but latent immunity from B or T cells is not really clear as far as I've read. 

utee94

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15347 on: September 01, 2021, 09:25:46 AM »
Cases in Austin/Travis County trending up a bit, again.  The age groups are skewing younger, more school-aged kids than ever before, so I think it's safe to say that the recent uptick is a result of school being back in session, and also that Delta is transmitting much more readily within those young age groups, than did previously.  More kids in the hospitals too, which is a really bad sign.

I think that if school had NOT gone back in session, we would be seeing the trend move quickly downward, as it was a few weeks ago.


FearlessF

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15348 on: September 01, 2021, 10:02:59 AM »
yet, no uproar to go to remote learning / closing schools

folks are tired of it
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Cincydawg

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15349 on: September 01, 2021, 11:25:31 AM »

After Delta took hold last winter in India, caseloads there rose sharply for slightly more than two months before plummeting at a nearly identical rate. In Britain, caseloads rose for almost exactly two months before peaking in July. In Indonesia, Thailand, France, Spain and several other countries, the Delta surge also lasted somewhere between 1.5 and 2.5 months.

* Between February and July 2021, depending on the country.The New York Times
And in the U.S. states where Delta first caused caseloads to rise, the cycle already appears to be on its downside. Case numbers in Arkansas, Florida, Louisiana, Mississippi and Missouri peaked in early or mid-August and have since been falling:



utee94

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15350 on: September 01, 2021, 11:27:51 AM »
Yeah they were plateauing here in Texico, too-- until school started back up.  I'm curious to see what happens over the next few weeks as schools open in more and more states.  Do their numbers continue to decline, or will they trend back upward as they have here?



Cincydawg

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15351 on: September 01, 2021, 11:28:14 AM »
The second plausible explanation involves human behavior. People don’t circulate randomly through the world. They live in social clusters, Jennifer Nuzzo, a Johns Hopkins epidemiologist, points out. Perhaps the virus needs about two months to circulate through a typically sized cluster, infecting the most susceptible — and a new wave starts when people break out of their clusters, such as during a holiday. Alternately, people may follow cycles of taking more and then fewer Covid precautions, depending on their level of concern.

Whatever the reasons, the two-month cycle predated Delta. It has repeated itself several times in the U.S., including both last year and early this year, with the Alpha variant, which was centered in the upper Midwest:

This is from the NYT, FYI.



utee94

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15352 on: September 01, 2021, 11:36:15 AM »
I think there are also strong effects from the amount of time spent inside vs. outside.  It's clear at this point the virus spreads much more easily inside.

Over the summer, southerners spent a lot of their leisure time inside to beat the heat.  Over the coming months, they'll be spending more time outside.

The trend in the north and midwest is the opposite.


betarhoalphadelta

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15353 on: September 01, 2021, 12:32:10 PM »
NPR article on longer-term immunity: https://www.npr.org/sections/goatsandsoda/2021/08/30/1032520934/immunity-to-covid-19-could-last-longer-than-youd-think

Nature journal study upon which the article is (partially) based: https://www.nature.com/articles/s41586-021-03738-2.pdf

One of the first I've seen that suggests that there is a long-term component of vaccine-derived immunity that occurs after the antibodies wane. 

We'll need more data on whether the boosters are actually necessary if this is the case. If it is purely based on antibody numbers, the booster might just be a cash grab by Pfizer/Moderna. That said, I wasn't afraid of the vaccine and I wouldn't hesitate to get the booster when my time comes in 8 months.

betarhoalphadelta

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15354 on: September 01, 2021, 12:33:29 PM »
Yeah they were plateauing here in Texico, too-- until school started back up.  I'm curious to see what happens over the next few weeks as schools open in more and more states.  Do their numbers continue to decline, or will they trend back upward as they have here?
I'm interested to see the difference in numbers (particularly in younger demographic, tied to schools) between Texas or Florida where masks mandates are illegal, and California where the state has mandated masks in schools statewide so it's not even a county-by-county or individual school district decision. 

FearlessF

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15355 on: September 01, 2021, 12:35:34 PM »
it would be interesting

my guess is that masks are not very effective in schools with kids, especially elementary age students
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Cincydawg

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15356 on: September 01, 2021, 12:36:23 PM »
I still can't explain India.  The "being outside" concept seems to work in the US, maybe, to an extent, as a reducer in spread.


847badgerfan

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Re: Coronavirus discussion and Quarantine ideas
« Reply #15357 on: September 01, 2021, 12:39:23 PM »
I'm interested to see the difference in numbers (particularly in younger demographic, tied to schools) between Texas or Florida where masks mandates are illegal, and California where the state has mandated masks in schools statewide so it's not even a county-by-county or individual school district decision.
Court overturned this. Districts in FL can mandate away.

BTW.. this article appeared in Forbes yesterday, but it was taken down (of course). Someone saved it.


School Mask Mandates Mean Trauma For Millions Of Children, Especially Those From Low-Income Families (outline.com)
U RAH RAH! WIS CON SIN!

 

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