The people in the highest at-risk groups will either have to remain locked down for a very long time, or make the decision that they're simply willing to take the risk in order to live a normal life.
My parents are certainly at-risk, and once I finally convinced them this wasn't a hoax, they've been diligent about distancing. But there is zero chance they will live their lives that way. In another month or so, as things reopen, I have no doubt that they're going to go back to being out and about. They'll wear masks when appropriate, I suspect. They'll distance at whatever is appropriate for the venue/timing. But they're not going to stay locked down. They don't want to live their lives that way, and they'll be willing to assume the risks.
It'll totally suck if they catch it and it harms them. It will also totally suck if my mom's cancer comes back and THAT harms her. Life is full of risks, and grown adults can make decisions for themselves.