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Topic: OT - Weird History
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Cincydawg · « **Reply #1596 on:** March 14, 2023, 09:00:56 AM »

Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. The first sulfonamide, trade-named Prontosil, was a prodrug. Experiments with Prontosil began in 1932 in the laboratories of Bayer AG, at that time a component of the huge German chemical trust IG Farben. The Bayer team believed that coal-tar dyes which are able to bind preferentially to bacteria and parasites might be used to attack harmful organisms in the body. After years of fruitless trial-and-error work on hundreds of dyes, a team led by physician/researcher Gerhard Domagk^[6] (working under the general direction of IG Farben executive Heinrich Hörlein) finally found one that worked: a red dye synthesized by Bayer chemist Josef Klarer that had remarkable effects on stopping some bacterial infections in mice.^[7] The first official communication about the breakthrough discovery was not published until 1935, more than two years after the drug was patented by Klarer and his research partner Fritz Mietzsch.^{[citation needed]}

Prontosil, as Bayer named the new drug, was the first medicine ever discovered that could effectively treat a range of bacterial infections inside the body. It had a strong protective action against infections caused by streptococci, including blood infections, childbed fever, and erysipelas, and a lesser effect on infections caused by other cocci. However, it had no effect at all in the test tube, exerting its antibacterial action only in live animals. Later, it was discovered by Daniel Bovet,^[8] Federico Nitti, and Jacques and Thérèse Tréfouël, a French research team led by Ernest Fourneau at the Pasteur Institute, that the drug was metabolized into two parts inside the body, releasing from the inactive dye portion a smaller, colorless, active compound called sulfanilamide.^[9] The discovery helped establish the concept of "bioactivation" and dashed the German corporation's dreams of enormous profit; the active molecule sulfanilamide (or sulfa) had first been synthesized in 1906 and was widely used in the dye-making industry; its patent had since expired and the drug was available to anyone.^[10]

The result was a sulfa craze.^[11] For several years in the late 1930s, hundreds of manufacturers produced myriad forms of sulfa. This and the lack of testing requirements led to the elixir sulfanilamide disaster in the fall of 1937, during which at least 100 people were poisoned with diethylene glycol. This led to the passage of the Federal Food, Drug, and Cosmetic Act in 1938 in the United States. As the first and only effective broad-spectrum antibiotic available in the years before penicillin, heavy use of sulfa drugs continued into the early years of World War II.^[12] They are credited with saving the lives of tens of thousands of patients, including Franklin Delano Roosevelt Jr. (son of US President Franklin Delano Roosevelt) and Winston Churchill.^[13]^[14] Sulfa had a central role in preventing wound infections during the war. American soldiers were issued a first-aid kit containing sulfa pills and powder and were told to sprinkle it on any open wound.^[15]

Cincydawg · « **Reply #1597 on:** March 16, 2023, 05:51:14 PM »

It ain't nearly as simple as driving a car. Navigation, for one thing, is interesting (preGPS).

Cincydawg · « **Reply #1598 on:** March 16, 2023, 05:57:48 PM »

12 March, 1971

On this day in 1971, American rock band the Allman Brothers Band began a two-night series of concerts at the Fillmore East in New York City; the shows were recorded and later released as a live album, "At Fillmore East", in July 1971 in the United States by Capricorn Records.

The live album features the band performing extended jam versions of songs such as "Whipping Post", "You Don't Love Me" and "In Memory of Elizabeth Reed." When first commercially released, it was issued as a double LP with just seven songs across four vinyl sides.

At Fillmore East was the band's artistic and commercial breakthrough, and is widely considered by some critics as one of the greatest live albums in rock music. It continues to be a top seller in the band's catalogue, and became their first album to go platinum.

In 2004, the album was selected for preservation in the US Library of Congress, deemed to be "culturally, historically, or aesthetically important" by the National Recording Registry.

MrNubbz · « **Reply #1599 on:** March 16, 2023, 07:51:19 PM »

Dwayne's not grabbing his crotch he's hiding a pipe they were passing around when the camerman was happening by. Possession wrap could have caused them to miss a gig - IMHO top 5 Album - EVA

😎

FearlessF · « **Reply #1600 on:** March 17, 2023, 09:14:12 AM »

THIS DAY IN HISTORY:

Rubber Band Patented (1845)
In 1845, Stephen Perry, a British inventor and businessman, patented what is now a staple office supply—the rubber band. While their intended function is to hold items together, rubber bands have been used in a number of other capacities; they can be wrapped around one another to form a bouncy ball or used as "ammunition" in rubber band guns. Though many modern rubber products are commonly made with synthetic rubber, rubber bands are still primarily manufactured using natural rubber.

Cincydawg · « **Reply #1601 on:** March 18, 2023, 09:09:57 AM »

1985 Cadillac Fleetwood Tested: The Downsized Caddy Disappoints (caranddriver.com)

Interestingly, I'd argue the Escalade has saved Caddy using much the same kind of approach.

Cincydawg · « **Reply #1602 on:** March 18, 2023, 09:13:33 AM »

USS Iowa's Tube #270, the first 16-inch/Mark 7 gun ever built, is in the process of being moved from storage at Norfolk Naval Shipyard to Fort Story where it will be placed on exhibit near the Old Cape Henry Lighthouse. Tube #270 was installed in Iowa's turret 1 until being removed in 1954 to be relined and saved as a spare.

FearlessF · « **Reply #1603 on:** March 18, 2023, 09:24:56 AM »

Quote from: Cincydawg on March 18, 2023, 09:09:57 AM

1985 Cadillac Fleetwood Tested: The Downsized Caddy Disappoints (caranddriver.com)

Interestingly, I'd argue the Escalade has saved Caddy using much the same kind of approach.

times have changed in 40 years

Cincydawg · « **Reply #1604 on:** March 18, 2023, 09:28:38 AM »

They have indeed, one of the car mags stated that Caddy makes the best BMWs today. It has not helped Caddy much to do that, all their profit is in SUVs (none of which are particularly compelling versus competition). They build some nice sedans and they just don't sell well.

Cincydawg · « **Reply #1605 on:** March 18, 2023, 09:30:01 AM »

It was a notion back in the day that these relationships would prevent a major war in Europe.

FearlessF · « **Reply #1606 on:** March 18, 2023, 09:39:10 AM »

if ya can't fight with your cousins, who can ya fight with?

Cincydawg · « **Reply #1607 on:** March 18, 2023, 09:51:21 AM »

847badgerfan · « **Reply #1608 on:** March 18, 2023, 09:55:41 AM »

Quote from: Cincydawg on March 18, 2023, 09:28:38 AM

They have indeed, one of the car mags stated that Caddy makes the best BMWs today. It has not helped Caddy much to do that, all their profit is in SUVs (none of which are particularly compelling versus competition). They build some nice sedans and they just don't sell well.

The '80's was the decade where the Big 3 all tried to kill themselves. So many terrible cars and so few good ones.

Cincydawg · « **Reply #1609 on:** March 18, 2023, 09:57:58 AM »

Cars in the 80s were all pretty bad, but the Hondas of the world were generally better. They had a tendency to rust though.

Rust today is practically nonexistent.

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Topic: OT - Weird History

Cincydawg

Re: OT - Weird History

Cincydawg

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Cincydawg

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MrNubbz

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FearlessF

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Cincydawg

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Cincydawg

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FearlessF

Re: OT - Weird History

Cincydawg

Re: OT - Weird History

Cincydawg

Re: OT - Weird History

FearlessF

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Cincydawg

Re: OT - Weird History

847badgerfan

Re: OT - Weird History

Cincydawg

Re: OT - Weird History