Michigan should theoretically overwhelm MTSU.
In terms of concerns, I'd definitely prefer that CB Ambry Thomas be back in the lineup since this is a team that generally runs out 4 WRs.
In terms of curiosity, it's mainly about the offense. We've heard enough words from coaches and insiders to expect the FB and huddle is gone, that the team can run tempo, that RPOs help constitute the base offense, and that the days are gone of the run and pass game not being married to one another, such that their formations seldom look the same. The spring game supported many of those bullets. But whereas we have inklings about structure, we have very little idea about how efficient and coherent the new offense will be. Likewise, we expect Cesar Ruiz, Shea Patterson, and the WRs to thrive under this structure, but they still have to actually show that it's true.
Also of curiosity is the extent to which the defense steps back. Before the 2017 season, the team lost 11 defenders to the NFL (8 drafted) and still ended up as a Top 5 unit. The losses going into this year aren't as bad (mainly just 3 great guys). However, the 2018 defense was also a rung below the 2016 unit that finished #1 nationally. How will these parts add up? Can Don Brown pull it off again and keep the unit in the Top 5? I bet he can't but that he can keep them in the Top 10. We'll see if either or both of those are wrong.