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Topic: CRISPR and AI

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FearlessF

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Re: CRISPR and AI
« Reply #112 on: February 10, 2026, 05:20:30 PM »
This is when I'm glad to be over the hill.
I'm already over the hill.
the youngsters can deal with it
"Courage; Generosity; Fairness; Honor; In these are the true awards of manly sport."

Gigem

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Re: CRISPR and AI
« Reply #113 on: February 11, 2026, 10:13:17 AM »
As an aside about AI, I put a query into Chat GPT about College Football awhile back.  I simply asked it to name all the Div 1 teams that A&M has played but never beat.  I kinda sorta knew a few of them, but it spit out an assortment of teams it claimed we never beat, that I knew with 100% certainty we beat.  I even prodded it along, asking it to check out such and such season.  

To me, the task seemed very simple.  Look at all the teams that we've played over the years, that are Div 1, and figure out which ones we've never beaten.  I'm sure that most of us fans know that there are quirks in the system like UT and Vanderbilt where Vandy had some lopsided record vs UT, but I don't think many of us track which teams we've never beaten.  I also asked for a list of teams we've never played.  It struggled mightily.  I basically had to ask it to look at certain seasons, the first such and such game, what was the result.  The whole time it kept confidently telling me about some outcome I know that wasn't true.  When I called it out, it would kinda sorta do a 180 but never fully acknowledge that essentially it's full of shit.  

bayareabadger

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Re: CRISPR and AI
« Reply #114 on: February 11, 2026, 10:30:01 AM »
It’s weird because some of the stuff that it doesn’t do is just so basic. Like I was trying to get it to pull some data from a website. And it could do it, but when I needed 25 entries, it would only get five and then it would stall.

Will be interesting to see how the use cases evolve. 

Gigem

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Re: CRISPR and AI
« Reply #115 on: February 11, 2026, 10:30:12 AM »
For those interested, the teams A&M has never beaten (but played) are Ohio State, Florida State, and Penn State.  There is an odd-ball in there like Cincinnati, that we maybe played once or twice over 100 years, but Chat GPT could not tell me much.  I think the list of teams we haven't even played is like Wash State or something.  I really don't even remember.  

FYI, Grok nailed both questions on the first try.  I will say that I didn't research it enough to know with 100% accuracy but some quick research yielded the same results.  

Gigem

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Re: CRISPR and AI
« Reply #116 on: February 11, 2026, 10:32:00 AM »
It’s weird because some of the stuff that it doesn’t do is just so basic. Like I was trying to get it to pull some data from a website. And it could do it, but when I needed 25 entries, it would only get five and then it would stall.

Will be interesting to see how the use cases evolve.
I asked Chat GPT to tell me about it's blind spots and weaknesses, and one of those is that it can't "see" live internet.  So if you tune in during a football game or something, it really doesn't know about it until later.  It has to be trained, and the training data is not live.  For example, I was "chatting" about CFP and it told me bummer about A&M not making it etc.  


Grok appears to be live in that regard.  

MikeDeTiger

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Re: CRISPR and AI
« Reply #117 on: February 11, 2026, 12:34:16 PM »
For those interested, the teams A&M has never beaten (but played) are Ohio State, Florida State, and Penn State.  There is an odd-ball in there like Cincinnati, that we maybe played once or twice over 100 years, but Chat GPT could not tell me much.  I think the list of teams we haven't even played is like Wash State or something.  I really don't even remember. 

FYI, Grok nailed both questions on the first try.  I will say that I didn't research it enough to know with 100% accuracy but some quick research yielded the same results. 

I think Nebraska and Penn St. are two teams we've played but never beaten.  That may not be exhaustive, though.  FSU might be in there.  Not sure who else.  

FearlessF

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Re: CRISPR and AI
« Reply #118 on: February 11, 2026, 12:37:12 PM »
"Courage; Generosity; Fairness; Honor; In these are the true awards of manly sport."

Gigem

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Re: CRISPR and AI
« Reply #119 on: February 11, 2026, 12:53:06 PM »
I think I may have misremembered Penn State. We may have won one in the 70’s or 80’s. 

But OSU and FSU are for sure. 

MikeDeTiger

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Re: CRISPR and AI
« Reply #120 on: February 11, 2026, 01:12:14 PM »
I think we're 1-1-1 against Ohio State.  I want to say we're 0-2 or 0-3 against Penn St.  I'd have to look it up, but it's something like that. 

EDIT: out of curiosity I looked it up.  It's 0-2 vs. PSU and 2-9 against FSU.  I couldn't remember if we'd ever beaten them or not, but apparently we did in 1968 and 1982. 

Honestbuckeye

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Re: CRISPR and AI
« Reply #121 on: Today at 09:45:41 AM »
Get your facts first, then you can distort them as you please.
-Mark Twain

betarhoalphadelta

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Re: CRISPR and AI
« Reply #122 on: Today at 10:05:44 AM »
Second one is paywalled...

Cincydawg

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Re: CRISPR and AI
« Reply #123 on: Today at 10:15:58 AM »
I keep reading that AI is really going to replace a LOT of more basic jobs and we'll have massive UE perhaps requiring UBI.

Honestbuckeye

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Re: CRISPR and AI
« Reply #124 on: Today at 10:28:40 AM »
      Think back to February 2020.

A few people were talking about a virus spreading overseas. If someone told you they were stockpiling toilet paper you would have thought they’d been spending too much time on a weird corner of the internet. Then, over the course of about three weeks, the entire world changed.

·
I think we’re in the “this seems overblown” phase of something much, much bigger than Covid.

I’ve spent six years building an AI startup and investing in the space. I live in this world. And I’m writing this for the people in my life who don’t. I keep giving them the polite, cocktail-party version. Because the honest version sounds like I’ve lost my mind. But the gap between what I’ve been saying and what is actually happening has gotten far too big. The people I care about deserve to hear what is coming, even if it sounds crazy.

I should be clear about something up front: even though I work in AI, I have almost no influence over what’s about to happen, and neither does the vast majority of the industry. The future is being shaped by a remarkably small number of people: a few hundred researchers at a handful of companies… OpenAI, Anthropic, Google DeepMind, and a few others.

·
Most of us who work in AI are building on top of foundations we didn’t lay. We’re watching this unfold the same as you… we just happen to be close enough to feel the ground shake first.

But it’s time now. Not in an “eventually we should talk about this” way. In a “this is happening right now and I need you to understand it” way.

I know this is real because it happened to me first
Here’s the thing nobody outside of tech quite understands yet: we’re not making predictions. We’re telling you what already occurred in our own jobs, and warning you that you’re next.

For years, AI had been improving steadily. Then in 2025, new techniques for building these models unlocked a much faster pace of progress. This year, something clicked. Not like a light switch… more like the moment you realize the water has been rising around you and is now at your chest.

·
I am no longer needed for the actual technical work of my job. I describe what I want built, in plain English, and it just… appears. Not a rough draft I need to fix. The finished thing. I tell the AI what I want, walk away from my computer for four hours, and come back to find the work done. Done well, done better than I would have done it myself, with no corrections needed. A couple of months ago, I was going back and forth with the AI, guiding it, making edits. Now I just describe the outcome and leave.

Let me give you an example so you can understand what this actually looks like in practice. I’ll tell the AI: “I want to build this app. Here’s what it should do, here’s roughly what it should look like. Figure out the user flow, the design, all of it.” And it does. It writes tens of thousands of lines of code. Then, and this is the part that would have been unthinkable a year ago, it opens the app itself. It clicks through the buttons. It tests the features. It uses the app the way a person would. If it doesn’t like how something looks or feels, it goes back and changes it, on its own. It iterates, like a developer would, fixing and refining until it’s satisfied. Only once it has decided the app meets its own standards does it come back to me and say: “It’s ready for you to test.” And when I test it, it’s usually perfect.

I’m not exaggerating. That is what my Monday looked like this week.

I’ve always been early to adopt AI tools. But the last few months have shocked me. These new AI models aren’t incremental improvements. This is a different thing entirely.

The experience that tech workers have had over the past year, of watching AI go from “helpful tool” to “does my job better than I do”, is the experience everyone else is about to have. Law, finance, medicine, accounting, consulting, writing, design, analysis, customer service. Not in 10 years. The people building these systems say one to five years. Some say less. The market was spooked enough this month that it wiped out $1 trillion worth of software value in just a week. And given what I’ve seen in just the last couple of months, I see more disruption, and soon.

“But I tried AI and it wasn’t that good”
If you tried ChatGPT in 2023 or early 2024 and thought “this makes stuff up” or “this isn’t that impressive”, you were right. Those early versions were genuinely limited. They hallucinated. They confidently said things that were nonsense.

The models available today are unrecognizable from what existed even six months ago. The debate about whether AI is “really getting better” or “hitting a wall” — which has been going on for over a year — is over. It’s done. Anyone still making that argument either hasn’t used the current models, has an incentive to downplay what’s happening, or is evaluating based on an experience from 2024 that is no longer relevant. I don’t say that to be dismissive. I say it because the gap between public perception and current reality is now enormous, and that gap is dangerous… because it’s preventing people from preparing.

Part of the problem is that most people are using the free version of AI tools. The free version is over a year behind what paying users have access to. Judging AI based on free-tier ChatGPT is like evaluating the state of smartphones by using a flip phone. The people paying for the best tools, and actually using them daily for real work, know what’s coming.

I think of my friend, who’s a lawyer. I keep telling him to try using AI at his firm, and he keeps finding reasons it won’t work. And I get it. But I’ve had partners at major law firms reach out to me for advice, because they’ve tried the current versions and they see where this is going. One of them, the managing partner at a large firm, spends hours every day using AI. He told me it’s like having a team of associates available instantly. He’s not using it because it’s a toy. He’s using it because it works. And he told me something that stuck with me: every couple of months, it gets significantly more capable for his work. He said if it stays on this trajectory, he expects it’ll be able to do most of what he does before long… and he’s a managing partner with decades of experience. He’s not panicking. But he’s paying very close attention.

Think about what that means for your work.

What this means for your job
I’m going to be direct with you because I think you deserve honesty more than comfort.

Dario Amodei, who is probably the most safety-focused CEO in the AI industry, has publicly predicted that AI will eliminate 50% of entry-level white-collar jobs within one to five years. And many people in the industry think he’s being conservative. Given what the latest models can do, the capability for massive disruption could be here by the end of this year. It’ll take some time to ripple through the economy, but the underlying ability is arriving now.

This is different from every previous wave of automation, and I need you to understand why. AI isn’t replacing one specific skill. It’s a general substitute for cognitive work. It gets better at everything simultaneously. When factories automated, a displaced worker could retrain as an office worker. When the internet disrupted retail, workers moved into logistics or services. But AI doesn’t leave a convenient gap to move into. Whatever you retrain for, it’s improving at that too.

I think the honest answer is that nothing that can be done on a computer is safe in the medium term. If your job happens on a screen (if the core of what you do is reading, writing, analyzing, deciding, communicating through a keyboard) then AI is coming for significant parts of it. The timeline isn’t “someday.” It’s already started.

Eventually, robots will handle physical work too. They’re not quite there yet. But “not quite there yet” in AI terms has a way of becoming “here” faster than anyone expects.

What you should actually do
I’m not writing this to make you feel helpless. I’m writing this because I think the single biggest advantage you can have right now is simply being early. Early to understand it. Early to use it. Early to adapt.

Start using AI seriously, not just as a search engine. Sign up for the paid version of Claude or ChatGPT. It’s $20 a month. But two things matter right away. First: make sure you’re using the best model available, not just the default. These apps often default to a faster, dumber model. Dig into the settings or the model picker and select the most capable option. Right now that’s GPT-5.2 on ChatGPT or Claude Opus 4.6 on Claude, but it changes every couple of months. If you want to stay current on which model is best at any given time, you can follow me on X (@mattshumer_). I test every major release and share what’s actually worth using.

Second, and more important: don’t just ask it quick questions. That’s the mistake most people make. They treat it like Google and then wonder what the fuss is about. Instead, push it into your actual work. If you’re a lawyer, feed it a contract and ask it to find every clause that could hurt your client. If you’re in finance, give it a messy spreadsheet and ask it to build the model. If you’re a manager, paste in your team’s quarterly data and ask it to find the story. The people who are getting ahead aren’t using AI casually. They’re actively looking for ways to automate parts of their job that used to take hours. Start with the thing you spend the most time on and see what happens.

And don’t assume it can’t do something just because it seems too hard. Try it. If you’re a lawyer, don’t just use it for quick research questions. Give it an entire contract and ask it to draft a counterproposal. If you’re an accountant, don’t just ask it to explain a tax rule. Give it a client’s full return and see what it finds. The first attempt might not be perfect. That’s fine. Iterate. Rephrase what you asked. Give it more context. Try again. You might be shocked at what works. And here’s the thing to remember: if it even kind of works today, you can be almost certain that in six months it’ll do it near perfectly. The trajectory only goes one direction.

This might be the most important year of your career. Work accordingly. I don’t say that to stress you out. I say it because right now, there is a brief window where most people at most companies are still ignoring this. The person who walks into a meeting and says “I used AI to do this analysis in an hour instead of three days” is going to be the most valuable person in the room. Not eventually. Right now. Learn these tools. Get proficient. Demonstrate what’s possible. If you’re early enough, this is how you move up: by being the person who understands what’s coming and can show others how to navigate it. That window won’t stay open long. Once everyone figures it out, the advantage disappears.

Have no ego about it. The managing partner at that law firm isn’t too proud to spend hours a day with AI. He’s doing it specifically because he’s senior enough to understand what’s at stake. The people who will struggle most are the ones who refuse to engage: the ones who dismiss it as a fad, who feel that using AI diminishes their expertise, who assume their field is special and immune. It’s not. No field is.

Get your financial house in order. I’m not a financial advisor, and I’m not trying to scare you into anything drastic. But if you believe, even partially, that the next few years could bring real disruption to your industry, then basic financial resilience matters more than it did a year ago. Build up savings if you can. Be cautious about taking on new debt that assumes your current income is guaranteed. Think about whether your fixed expenses give you flexibility or lock you in. Give yourself options if things move faster than you expect.

Think about where you stand, and lean into what’s hardest to replace. Some things will take longer for AI to displace. Relationships and trust built over years. Work that requires physical presence. Roles with licensed accountability: roles where someone still has to sign off, take legal responsibility, stand in a courtroom. Industries with heavy regulatory hurdles, where adoption will be slowed by compliance, liability, and institutional inertia. None of these are permanent shields. But they buy time. And time, right now, is the most valuable thing you can have, as long as you use it to adapt, not to pretend this isn’t happening.

Rethink what you’re telling your kids. The standard playbook: get good grades, go to a good college, land a stable professional job. It points directly at the roles that are most exposed. I’m not saying education doesn’t matter. But the thing that will matter most for the next generation is learning how to work with these tools, and pursuing things they’re genuinely passionate about. Nobody knows exactly what the job market looks like in ten years. But the people most likely to thrive are the ones who are deeply curious, adaptable, and effective at using AI to do things they actually care about. Teach your kids to be builders and learners, not to optimize for a career path that might not exist by the time they graduate.

Your dreams just got a lot closer. I’ve spent most of this section talking about threats, so let me talk about the other side, because it’s just as real. If you’ve ever wanted to build something but didn’t have the technical skills or the money to hire someone, that barrier is largely gone. You can describe an app to AI and have a working version in an hour. I’m not exaggerating. I do this regularly. If you’ve always wanted to write a book but couldn’t find the time or struggled with the writing, you can work with AI to get it done. Want to learn a new skill? The best tutor in the world is now available to anyone for $20 a month… one that’s infinitely patient, available 24/7, and can explain anything at whatever level you need. Knowledge is essentially free now. The tools to build things are extremely cheap now. Whatever you’ve been putting off because it felt too hard or too expensive or too far outside your expertise: try it. Pursue the things you’re passionate about. You never know where they’ll lead. And in a world where the old career paths are getting disrupted, the person who spent a year building something they love might end up better positioned than the person who spent that year clinging to a job description.

Build the habit of adapting. This is maybe the most important one. The specific tools don’t matter as much as the muscle of learning new ones quickly. AI is going to keep changing, and fast. The models that exist today will be obsolete in a year. The workflows people build now will need to be rebuilt. The people who come out of this well won’t be the ones who mastered one tool. They’ll be the ones who got comfortable with the pace of change itself. Make a habit of experimenting. Try new things even when the current thing is working. Get comfortable being a beginner repeatedly. That adaptability is the closest thing to a durable advantage that exists right now.

Here’s a simple commitment that will put you ahead of almost everyone: spend one hour a day experimenting with AI. Not passively reading about it. Using it. Every day, try to get it to do something new… something you haven’t tried before, something you’re not sure it can handle. Try a new tool. Give it a harder problem. One hour a day, every day. If you do this for the next six months, you will understand what’s coming better than 99% of the people around you. That’s not an exaggeration. Almost nobody is doing this right now. The bar is on the floor.

What I know
I know the next two to five years are going to be disorienting in ways most people aren’t prepared for. This is already happening in my world. It’s coming to yours.

I know the people who will come out of this best are the ones who start engaging now — not with fear, but with curiosity and a sense of urgency.

We’re past the point where this is an interesting dinner conversation about the future. The future is already here. It just hasn’t knocked on your door yet.

It’s about to.



Get your facts first, then you can distort them as you please.
-Mark Twain

847badgerfan

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Re: CRISPR and AI
« Reply #125 on: Today at 11:07:37 AM »
I wonder how it would do in my field.

"Hey, AI, go out to this jobsite and gather some notes on how construction is progressing. While you are there, I need you to pound some stakes in the ground for some additional storm sewer construction."

"Hey, AI, I need you to go out to (random county) and do boundary recon so we can survey this original government section 3-45-12. We'll need to gather the location of points, including re-establishing those that are lost or obliterated, verify evidence of possession, like fence lines, tree lines, pavement, etc. Take the GPS with you and make sure you occupy every point for at least 5 minutes."

Could that happen? If so, I'm glad I have one foot out the door.
U RAH RAH! WIS CON SIN!

 

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