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Topic: CRISPR and AI

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OrangeAfroMan

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Re: CRISPR and AI
« Reply #98 on: August 17, 2025, 01:11:13 PM »
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betarhoalphadelta

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Re: CRISPR and AI
« Reply #99 on: December 18, 2025, 10:02:13 AM »
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MikeDeTiger

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Re: CRISPR and AI
« Reply #100 on: December 18, 2025, 11:43:18 AM »
At first I thought the bottom of that cartoon said "Alarmingly Brad." 
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betarhoalphadelta

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Re: CRISPR and AI
« Reply #101 on: February 08, 2026, 12:30:03 PM »
Came across this and thought it was absolutely excellent...

https://www.latent.space/p/adversarial-reasoning

A small excerpt below, but I highly recommend going and reading the whole thing...


Quote
LLMs dominate chess-like domains
Not every domain follows poker dynamics. You have certain fields very close to chess, and LLMs are already poised to be successful in them.

Writing code is probably the most clear example:

  • System is deterministic
  • Rules are fixed and explicit
  • No hidden state that matters
  • Correctness is objective and verifiable
  • No agent is actively trying to counter the model
The same “closed world” structure shows up in others: Math / Formal proofs, data transformation, translation, factual research, compliance heavy clerical work (invoice matching, reconciliation), where you can iterate towards the right move without needing a “theory of the mind”.

The important caveat is that many domains are chess-like in their technical core but become poker-like in their operational context.

Professional software engineering extends well beyond the chess-like core. Understanding ambiguous requirements means modeling what the stakeholder actually wants versus what they said. Writing good APIs means anticipating how other developers will misuse them. Code review is social: you’re modeling reviewers’ preferences and concerns. Architectural decisions account for unknown future requirements and organizational politics. That is, the parts outsiders don’t see but senior engineers spend much of their time simulating.

The parts that look like the job are chess (like). The parts that are the job are poker.

Difficulty is orthogonal to “openness” of a domain. Proving theorems is hard. Negotiating salary is easy. But theorem-proving is chess-shaped and negotiation is poker-shaped.

This is why the disconnect between experts and outsiders is domain-specific. Ask a competitive programmer if AI can solve algorithm problems, and they’ll say yes because they’ve watched it happen. Ask a litigator if AI can handle depositions, and they’ll laugh because they live in a world where every word is a move against an adversary who’s modeling them back.

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CatsbyAZ

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Re: CRISPR and AI
« Reply #102 on: Today at 11:08:06 AM »
Watching the Super Bowl last Sunday, every other commercial was for an A.I. product; commercials for Gemini (Google), Codex (OpenAI), Claude (Anthropic), Microsoft Copilot, Meta’s AI smart sunglasses, Amazon Alexa, Genspark, and Base 44. It got to the point where the kids at the party I was at, who were playing a game of guessing what the commercials were for, started shouting AI(!) at the start of every commercial, regardless of what it was obviously for: Skechers, TurboTax, Pringles, Volkswagen. Other commercials were AI-enhanced (Dunkin Donuts) or entirely AI-generated like Svedka Vodka's spot (see below).

From an economic standpoint, stocks for the Magnificent Seven (M7) were very well represented according to their AI Super Bowl commercials: Google, Microsoft, Meta, and Amazon. And even that under represents just how much the M7s have staked their futures into AI development considering how OpenAI is 27% owned by Microsoft and both Google and Amazon have billions invested into Anthropic.

And of the three M7s not mentioned: 1) Tesla owns Grok, 2) Apple owns Apple Intelligence, and 3) NVIDIA is both the primary hardware provider and the leading infrastructure builder for AI.

In other words the companies for the seven stocks that comprise over one-third of the stock market's total capitalization are largely staking their direction into wherever AI development leads. That seems an economic risk: tying one-third of the stock market so heavily into developing technologies that are no guarantee to turn consistent consumer profits screams of a bubble that is too big to burst.


https://twitter.com/bearlyai/status/2020531301909196891
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bayareabadger

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Re: CRISPR and AI
« Reply #103 on: Today at 11:16:13 AM »
Quote from: CatsbyAZ on Today at 11:08:06 AM
Watching the Super Bowl last Sunday, every other commercial was for an A.I. product; commercials for Gemini (Google), Codex (OpenAI), Claude (Anthropic), Microsoft Copilot, Meta’s AI smart sunglasses, Amazon Alexa, Genspark, and Base 44. It got to the point where the kids at the party I was at, who were playing a game of guessing what the commercials were for, started shouting AI(!) at the start of every commercial, regardless of what it was obviously for: Skechers, TurboTax, Pringles, Volkswagen. Other commercials were AI-enhanced (Dunkin Donuts) or entirely AI-generated like Svedka Vodka's spot (see below).

From an economic standpoint, stocks for the Magnificent Seven (M7) were very well represented according to their AI Super Bowl commercials: Google, Microsoft, Meta, and Amazon. And even that under represents just how much the M7s have staked their futures into AI development considering how OpenAI is 27% owned by Microsoft and both Google and Amazon have billions invested into Anthropic.

And of the three M7s not mentioned: 1) Tesla owns Grok, 2) Apple owns Apple Intelligence, and 3) NVIDIA is both the primary hardware provider and the leading infrastructure builder for AI.

In other words the companies for the seven stocks that comprise over one-third of the stock market's total capitalization are largely staking their direction into wherever AI development leads. That seems an economic risk: tying one-third of the stock market so heavily into developing technologies that are no guarantee to turn consistent consumer profits screams of a bubble that is too big to burst.


https://twitter.com/bearlyai/status/2020531301909196891
Is there such thing as a bubble too big to burst?
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utee94

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Re: CRISPR and AI
« Reply #104 on: Today at 11:21:46 AM »
I always look at AI projects and endeavors on a timeline.

I start at 100 years from now.  100 years from now, will AI be doing a vast array of jobs and supplying a huge amount of human-consumed content?  The answer to that is-- yes, of course, absolutely.  AI will be completely dominant 100 years from now.  I'm hopeful that if true sentient AI evolves (or alternatively something that simply mimics true sentience extremely well, which is effectively the same thing), it will be peaceful and benign.  Indeed, I'm assuming this to be true, and in the past I've outlined several reasons why.

So then I say, 50 years from now, will AI be taking over this thing or that?  The answer, again, is-- absolutely.  AI is evolving quickly, and it's foolish to think it won't be massively influential in 50 years.

So then I go on to 25, 15, 10, and then 5 years.

Everything we can imagine humans doing, or AI doing, is going to fall somewhere on that timeline.  Twenty years ago, we can safely assume that AI was doing very little of it.  100 years from now, I believe we can safely assume that AI will be doing a ton of it.

When does the balance shift?  Will it be gradual?  Or will it be "tippy?"  

Either way, 15 years from now I think AI is going to be pretty massive.  So my point is, I don't see a ton of risk in these huge corporations investing heavily in AI hardware and software, in AI projects and infrastructure, or in the idea that AI is going to be the single biggest thing in modern human history. Will there be some huge misses along the way?  Absolutely.  There already have been.  In total, though, I don't see any possibility that AI won't be incredibly important and influential, and that the shift is going to happen sooner rather than later.

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FearlessF

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Re: CRISPR and AI
« Reply #105 on: Today at 12:12:09 PM »
The University of Nebraska System introduced an AI Institute Monday that will position Nebraska as a “leader” in the future of AI.

The AI Institute will bring together emerging technologies, grow future economies and support future generations through “human-centered” AI research, University of Nebraska President Jeffrey Gold said in an email sent to students, faculty and staff Monday morning.

The AI Institute's research will cover areas like healthcare, agriculture, rural and urban development, business and national security. It will also coordinate research, teaching and engagement efforts across the NU System, while utilizing its strengths across campuses, Gold said in the email.


The AI Institute will be co-directed by UNL professors Santosh Pitla, a professor of Biological Systems Engineering and Adrian Wisnicki, a professor of English. It will conduct AI research, teaching and engagement efforts across the NU System.

The AI Institute will be built on recommendations from the NU AI Task Force, a faculty-led group that developed a system roadmap for how the university interacts with AI across research, teaching, outreach and service, Gold said in the email.

The NU System will pursue federal grants, public-private partnerships with industry leaders and collaborate with Nebraska policymakers to fund and grow AI research under the AI Institute, according to a report from the AI Task Force.

More information about the NU AI Institute can be found here.

news@dailynebraskan.com
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Gigem

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Re: CRISPR and AI
« Reply #106 on: Today at 03:41:52 PM »
Quote from: utee94 on Today at 11:21:46 AM
I always look at AI projects and endeavors on a timeline.

I start at 100 years from now.  100 years from now, will AI be doing a vast array of jobs and supplying a huge amount of human-consumed content?  The answer to that is-- yes, of course, absolutely.  AI will be completely dominant 100 years from now.  I'm hopeful that if true sentient AI evolves (or alternatively something that simply mimics true sentience extremely well, which is effectively the same thing), it will be peaceful and benign.  Indeed, I'm assuming this to be true, and in the past I've outlined several reasons why.

So then I say, 50 years from now, will AI be taking over this thing or that?  The answer, again, is-- absolutely.  AI is evolving quickly, and it's foolish to think it won't be massively influential in 50 years.

So then I go on to 25, 15, 10, and then 5 years.

Everything we can imagine humans doing, or AI doing, is going to fall somewhere on that timeline.  Twenty years ago, we can safely assume that AI was doing very little of it.  100 years from now, I believe we can safely assume that AI will be doing a ton of it.

When does the balance shift?  Will it be gradual?  Or will it be "tippy?" 

Either way, 15 years from now I think AI is going to be pretty massive.  So my point is, I don't see a ton of risk in these huge corporations investing heavily in AI hardware and software, in AI projects and infrastructure, or in the idea that AI is going to be the single biggest thing in modern human history. Will there be some huge misses along the way?  Absolutely.  There already have been.  In total, though, I don't see any possibility that AI won't be incredibly important and influential, and that the shift is going to happen sooner rather than later.
I tend to have the same outlook, and furthermore I expand AI to robots and humanoid robots (whatever you want to call them).  

I believe we are on a ~20 year timeline for even the most labor intensive jobs there are. The only humans left working will be the ones where robots simply can't handle the mud or conditions.  
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bayareabadger

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Re: CRISPR and AI
« Reply #107 on: Today at 03:56:46 PM »
The potential post-job world For a lot of people is going to be interesting.
« Last Edit: Today at 04:02:18 PM by bayareabadger »
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847badgerfan

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Re: CRISPR and AI
« Reply #108 on: Today at 04:03:02 PM »
This is when I'm glad to be over the hill.
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betarhoalphadelta

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Re: CRISPR and AI
« Reply #109 on: Today at 04:24:29 PM »
Quote from: utee94 on Today at 11:21:46 AM
Either way, 15 years from now I think AI is going to be pretty massive.  So my point is, I don't see a ton of risk in these huge corporations investing heavily in AI hardware and software, in AI projects and infrastructure, or in the idea that AI is going to be the single biggest thing in modern human history. Will there be some huge misses along the way?  Absolutely.  There already have been.  In total, though, I don't see any possibility that AI won't be incredibly important and influential, and that the shift is going to happen sooner rather than later.
Yes, but the counterpoint is that irrational exuberism is... Irrational exuberism. 

In the late 90s, the internet was arriving. Everything you said about AI being big eventually was said about the internet in the late 90s. And every single bit of it was true. 

And yet "dot com" was still a bubble, and that bubble burst. A lot of companies met their end. A lot of investors lost their shirts. And the internet we know today was built by the survivors.

Now--I'll say the scariest of all words for any investor--in some ways, it's different this time... The companies going at it today are not spending IPO dollars / venture capital / funny money on this stuff. They're wildly profitable massive corporations who can afford to keep the gravy train going right now, and for a good while longer. 

I think AI is going to be one of the biggest things in human history. But there's always a chance that there's going to be a GIANT drop in the roller coaster ride from where we are before we ascend to those higher peaks...
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utee94

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Re: CRISPR and AI
« Reply #110 on: Today at 04:34:09 PM »
Quote from: betarhoalphadelta on Today at 04:24:29 PM
Yes, but the counterpoint is that irrational exuberism is... Irrational exuberism.

In the late 90s, the internet was arriving. Everything you said about AI being big eventually was said about the internet in the late 90s. And every single bit of it was true.

And yet "dot com" was still a bubble, and that bubble burst. A lot of companies met their end. A lot of investors lost their shirts. And the internet we know today was built by the survivors.

Now--I'll say the scariest of all words for any investor--in some ways, it's different this time... The companies going at it today are not spending IPO dollars / venture capital / funny money on this stuff. They're wildly profitable massive corporations who can afford to keep the gravy train going right now, and for a good while longer.

I think AI is going to be one of the biggest things in human history. But there's always a chance that there's going to be a GIANT drop in the roller coaster ride from where we are before we ascend to those higher peaks...


Yes, I suppose I'm talking most specifically about IT investments from these types of companies, because those are the ones that Catsbu brought up as the original topic for discussion.

There have already been numerous small-time and/or fly-by-night operations that have failed, and there will no doubt be countless more.  And there will also be huge investitures from big-time corporations that will ultimately end up as misplaced bets on failed or instantly surpassed technologies.  Heck my own company has already shelved more AI programs than most companies have had the resources to begin.

But still, we persist.  Because it IS indubitably the next big thing. And the next big thing is going to be... massive.
« Last Edit: Today at 04:44:02 PM by utee94 »
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betarhoalphadelta

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Re: CRISPR and AI
« Reply #111 on: Today at 04:59:57 PM »
Quote from: utee94 on Today at 04:34:09 PM
Yes, I suppose I'm talking most specifically about IT investments from these types of companies, because those are the ones brought up in the original topic of discussion.  There have already been numerous small-time and/or fly-by-night operations that have failed, and there will no doubt be countless more.  And there will also be huge investitures from big-time corporations that are ultimately bets on failed or instantly surpassed technologies.  Heck my own company has already shelved more AI programs than most companies have had the resources to begin.

But still, we persist.  Because it IS indubitably the next big thing. And the next big thing is going to be... massive.
Yep. Agree with you 100%.

However it might still be an investment bubble... And when 7 companies market cap makes up a third of the entire S&P 500 market cap as @CatsbyAZ points out... And that combined market cap has quadrupled since 2019... It's a little concerning...



If the massive AI investments don't actually start producing the projected earnings fast enough, what happens to those valuations? And if it's bad, what happens to everyone and their 401K, or brokerage accounts, or pension / retirement savings? 

But again, things are also different... These are tech companies trading in the 25-30 forward PE multiple range (NVDA outlier at 40). That's not crazy valuation for tech. So maybe despite the fact that we've got 7 companies taking up the a third of the S&P 500 isn't actually as terrifying as it sounds...  

So put me in the "cautiously optimistic" camp. 
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