I'll go with a weird one.
2002 Penn State.
They lost to Iowa in OT in a poorly officiated game. A complete pass in OT was called incomplete by an official. Iowa would go undefeated in the B1G that year.
They lost to Michigan away in OT in another poorly officiated game. Late in the fourth, Penn State completed a pass to Tony Johnson in which he got both feet in bounds, but the officials called it incomplete. This play would have put Penn State in FG range for the game winning score. Michigan would finish the season ranked #9 in the country.
They lost to Ohio State away by a score of 7-13. Ohio State completed a LONG 3rd down pass in which the ball hit the turf nearly 3 yards in front of the receiver, and bounced into his hands. Called complete by the official. This allowed OSU to run more time and hit a field goal, not to mention the flip in field position. On the preceding series, a long pass to Bryant Johnson was foiled by blatant pass interference. Chris Gamble (OSU), the interfering player making his first start on defense, said afterwards, "I tapped him a little early and was relieved when there was no flag." Ohio State would go undefeated in the B1G and win the national championship.
This season changed Paterno's view on instant replay and it was implemented by the B1G two years later.
They also lost to Auburn in their bowl game by a score of 9-13. Auburn scored a TD with 2:13 left in the game to take the lead for good.
A season in which Penn State caught every bad break there was.