It would take WAY too long to do, but I'd be curious to see it in relation to best possible opponent.
Because simply adding up the seeds doesn't tell the whole story, because the highest seeded teams, are always going to start against a 15 or 16, and then get a 7, 8, ,9 10.
So for a 3 seed, the toughest path would be 14-6-2-1 = 23. Kansas State got 14-6-7(+5)-9(+8), so it was overall a +13 in terms of bracket collapse.
That 2001 MSU 16-9-12-11, vs. 16-8-4-2 is +18.
It actually might be the 2018 Kansas State that benefitted from the first 16 over 1, and got a #11 in the Elite 8. 8-16-5-11. That's a +25. And they still lost to Loyola