I think more than 1 game in 20 is meaningful in FBS. A lot of teams are on the cusp of a bowl bid, or a better bowl bid. Nearly every regional FBS game OOC is interesting and meaningful. Well, if Vandy plays Notre Dame, it might not be, unless Vandy wins.
UGA this year has two pastries, two meaningful OOC games, and 8 conference games, all of which I consider meaningful, even if they are heavy favorites in a couple. That;s 10 out of 12, which is pretty good.