| WEEK 1 - AUGUST 31 | |
| (Thu) 9:00 | South Dakota State at Minnesota | FS1 |
| (Fri) 7:00 | Wisconsin at South Florida | ESPN |
| Tulsa at Michigan State | FS1 |
| (Fri) 7:15 | Massachusetts at Rutgers | BTN |
| (Fri) 9:30 | Purdue at Nevada | CBSSN |
| NOON | Florida Atlantic at Ohio State | FOX |
| South Alabama at Nebraska | ESPN |
| Indiana vs. Ball State @ Indianapolis | CBSSN |
| Akron at Illinois | BTN |
| Howard at Maryland | BTN |
| Idaho at Penn State | BTN |
| 4:00 | Northwestern at Stanford | FOX |
| 7:30 | Miami(Ohio) at Iowa | FS1 |
| Middle Tennessee at Michigan | BTN |
| | . |
| WEEK 2 - SEPTEMBER 7 | |
| NOON | Cincinnati at Ohio State | ABC |
| Army at Michigan | FOX |
| Syracuse at Maryland | ESPN/espn2 |
| Rutgers at Iowa | FS1 |
| Vanderbilt at Purdue | BTN |
| 3:30 | Nebraska at Colorado | FOX |
| Illinois at Connecticut | CBSSN |
| Central Michigan at Wisconsin | BTN |
| Eastern Illinois at Indiana | BTN |
| 7:30 | Buffalo at Penn State | FOX |
| Western Michigan at Michigan State | BTN |
| 10:30 | Minnesota at Fresno State | CBSSN |
| | . |
| WEEK 3 - SEPTEMBER 14 | |
| NOON | Pittsburgh at Penn State | ABC |
| Ohio State at Indiana | FOX |
| Maryland at Temple | CBSSN |
| Eastern Michigan at Illinois | BTN |
| 3:30 | Georgia Southern at Minnesota | BTN |
| UNLV at Northwestern | BTN |
| 4:00 | Arizona State at Michigan State | FOX |
| Iowa at Iowa State | FS1 |
| 7:30 | TCU at Purdue | BTN |
| 8:00 | Northern Illinois at Nebraska | FS1 |
| | . |
| WEEK 4 - SEPTEMBER 21 | |
| NOON | Michigan at Wisconsin | FOX |
| TBA | Nebraska at Illinois | |
| Michigan State at Northwestern | |
| Connecticut at Indiana | |
| Miami(Ohio) at Ohio State | |
| Boston College at Rutgers | |
| | . |
| WEEK 5 - SEPTEMBER 28 | |
| (Fri) 8:00 | Penn State at Maryland | FS1 |
| 3:30 | Indiana at Michigan State (Michigan State Homecoming) | |
| TBA | Middle Tennessee at Iowa | ESPN/espn2/ESPNU |
| Rutgers at Michigan | |
| Minnesota at Purdue | |
| Ohio State at Nebraska | |
| Northwestern at Wisconsin | |
| | . |
| WEEK 6 - OCTOBER 5 | |
| NOON | Purdue at Penn State (Penn State Homecoming) | ABC/ESPN/espn2 |
| Iowa at Michigan (Michigan Homecoming) | |
| 3:30 | Illinois at Minnesota (Minnesota Homecoming) | |
| Northwestern at Nebraska (Nebraska Homecoming) | ABC/ESPN |
| 7:30 | Michigan State at Ohio State (Ohio State Homecoming) | |
| TBA | Maryland at Rutgers | |
| Kent State at Wisconsin | |
| | . |
| WEEK 7 - OCTOBER 12 | |
| NOON | Rutgers at Indiana (Indiana Homecoming) | |
| Maryland at Purdue (Purdue Homecoming) | |
| 3:30 | Michigan State at Wisconsin (Wisconsin Homecoming) | |
| TBA | Michigan at Illinois | ABC/ESPN/espn2 |
| Penn State at Iowa | |
| Nebraska at Minnesota | |
| | . |
| WEEK 8 - OCTOBER 19 | |
| (Fri) 8:30 | Ohio State at Northwestern | FS1 |
| NOON | Wisconsin at Illinois (Illinois Homecoming) | BTN |
| Purdue at Iowa (Iowa Homecoming) | |
| 3:30 | Minnesota at Rutgers (Rutgers Homecoming) | |
| TBA | Indiana at Maryland | |
| Michigan at Penn State | |
| | . |
| WEEK 9 - OCTOBER 26 | |
| NOON | Iowa at Northwestern (Northwestern Homecoming) | |
| TBA | Illinois at Purdue | |
| Indiana at Nebraska | |
| Maryland at Minnesota | ABC/ESPN/espn2 |
| Penn State at Michigan State | |
| Wisconsin at Ohio State | |
| Notre Dame at Michigan | ABC/ESPN/espn2 |
| Liberty at Rutgers | |
| | . |
| WEEK 10 - NOVEMBER 2 | |
| NOON | Michigan at Maryland (Maryland Homecoming) | |
| TBA | Rutgers at Illinois | |
| Northwestern at Indiana | |
| Nebraska at Purdue | |
| | . |
| WEEK 11 - NOVEMBER 9 | |
| Illinois at Michigan State | |
| Iowa at Wisconsin | |
| Maryland at Ohio State | |
| Penn State at Minnesota | |
| Purdue at Northwestern | |
| | . |
| WEEK 12 - NOVEMBER 16 | |
| Indiana at Penn State | |
| Minnesota at Iowa | |
| Michigan State at Michigan | |
| Wisconsin at Nebraska | |
| Ohio State at Rutgers | |
| Massachusetts at Northwestern | |
| | . |
| WEEK 13 - NOVEMBER 23 | |
| Illinois at Iowa | |
| Michigan at Indiana | |
| Nebraska at Maryland | |
| Michigan State at Rutgers | |
| Minnesota at Northwestern | |
| Penn State at Ohio State | |
| Purdue at Wisconsin | |
| | . |
| WEEK 14 - NOVEMBER 30 | |
| (Fri) 2:30 | Iowa at Nebraska | BTN |
| NOON | Ohio State at Michigan | FOX |
| TBA | Northwestern at Illinois | |
| Indiana at Purdue | |
| Maryland at Michigan State | |
| Wisconsin at Minnesota | |
| Rutgers at Penn State | |
| | . |
| WEEK 15 | |
| 8:00 | Big Ten Championship Game | FOX |
| | |