| QB | ||
| RB | ||
| RB | ||
| WR | ||
| WR | ||
| TE | ||
| T | Taylor Decker | 12-15 |
| G | Andrew Norwell | 10-13 |
| C | Pat Elflein | 12-16 |
| G | Wyatt Davis | 17-present |
| T | Jack Mewhort | 10-13 |
| . | ||
| DE | Joey Bosa | 13-15 |
| DT | Michael Bennett | 11-14 |
| DT | Jonathan Hankins | 10-12 |
| DE | Chase Young | 17-19 |
| LB | Ryan Shazier | 11-13 |
| LB | Darron Lee | 13-15 |
| LB | Raekwon McMillan | 14-16 |
| CB | Marshon Lattimore | 14-16 |
| CB | Denzel Ward | 15-17 |
| S | Malik Hooker | 14-16 |
| S | ||
| . | ||
| K | ||
| P |