Yup, in my first professional life I was final test engineer for ion implanters, and I'd occasionally have to work with the techs to clean photomasks from wafers we'd test-burned in my implanters. HF will pass through your skin without affecting it much, but eats away at the bones once it reaches them. Suffice to say the PPE for that job was extensive.
For source material during ion implantation, I also got to handle solid arsenic and phosphorous, as well as Arsine, Phosphine, Boron Triflouride and Silicon Tetraglouride gases. All of which are very very nasty stuff. SCBA was required for all of that handling.