Sure. If I'm being asked to travel to the couple's hometown because it's convenient for the family of the bride and/or groom, that's one thing.
Yeah, when you grew up in Chicago, went to Purdue, then moved to California, most of the people you know are having a "destination wedding", at least for you. I got to see beautiful Noblesville, IN a few times!

I do find that destination weddings are a lot less of a problem for later in life weddings (whether it's a couple who just didn't get married young, or people on their second attempt). I think by that point you're inviting people who have gotten to a place where they have some money, you're not inviting 200 people because you "have to" include "everyone", so the people you're inviting are the people who would REALLY want to be there no matter where the wedding is.
That was what my buddy did for his (2nd) marriage at age 38. He was from Indy, lived in SoCal, and his to-be-wife was from SoCal. He decided to make his wedding [nearly] equally inconvenient for everyone, but had it at the Buffalo Trace distillery in Kentucky. That was a blast!
I didn't do any of that. My wife and I had the legal ceremony (same friend I just mentioned officiated it) at our wine bar with about 10 people, and then we went to Italy and eloped, having the actual ceremony be just the two of us, the officiant, and a photographer, in Florence. We ended up throwing a small reception when we got back, but that was just so that we had a way to include my kids. If neither of us had any kids, we'd not have done that.