As I said, Purdue is a very aggressive defense that can stall out drives by putting offenses behind down and distance with negative plays. But the flip side is that Purdue's defense can be gashed by big plays due to that aggressiveness.
Ohio State has multiple receivers who are big-play threats on every down.
This is a combination where Ohio State is a threat to score on every down and distance in any part of the field. And they're gonna hit on a few of those.
The only way Purdue wins is through getting Ohio State to turn the ball over multiple times, for Stroud to flat out miss a couple of receivers who are wide open, and to find themselves in short fields and/or defensive scores in the process of their aggressiveness.
If Ohio State plays a clean game offensively without a lot of forced or unforced errors, they'll massacre the Boilers. Their offense is too potent for Purdue to keep from giving up big plays.
