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So here's one for the offseason. What are some of the most amazing or groundbreaking or even flabbergasting things that you've seen in the world that have come about due to feats of science?

I'll kick it off. My father in law has terrible hearing. As in "not that far from deaf" hearing. When tested for sentence accuracy (HINT test; being able to hear and recite words in a sentence purely auditory so you can't read lips amongst background noise) he scored 19%, which is terrible. 

About two months ago, he had surgery to install a cochlear implant. The device bypasses all your natural hearing physiology, and directly electrically stimulates your auditory nerve based on the output of a processor translating sound into signal. 

After a few weeks to heal up, they turned it on in early April. Sunday was the first day we saw him since then. He said when he first got it turned on, it was almost like bleeps and bloops; he described it as "sounding" like R2D2. But through the therapy associated with it, it's been consistently getting better since then as his brain has started to associate the new electrical signals from the processor into something that he can identify as speech. He's even started to pick up and identify other sounds he hasn't heard in years, such as birds chirping, etc. It's not entirely easy, because his brain has to re-learn the association between electrical impulses that aren't identical to how his physiological hearing generated stimulus to his auditory nerve, but it's been slowly coming back. He even said that while music (which he's always LOVED) is still not quite there, he had a Pink Floyd song come on the radio and suddenly it coalesced into sounding like what it's supposed to. 

A few days before Sunday, he had gotten his retest on the HINT. He scored 89%, which is in the "normal to mild impairment" category. Which is absolutely fantastic. And it's likely to continue to improve over time. 

To me, that's an astounding thing. Humanity created an electronic processor that bypasses all normal hearing and directly stimulates the auditory nerve, and now my FIL who was near deaf can hear almost normally. 

Who else has something amazing? 

I've mentioned the Haber-Bosch process before.  

Most of what "we" know about is really technology, not science.  Science often has no immediate practical use in its developments, though scientists often do more practical development work using science.

A room temperature superconductor had been "on the horizon" for decades now, but we don't have it, we don't even have one that works at -78°C.  

The discovery of using fire to cook food is an amazing feat.

The development of the wheel. Amazing.

Although fire and cooking food kinda enabled all the rest of it, if you believe the book Sapiens. Cooking food made it easier to digest, providing a lot more energy for the brain. 

Some science feats that impress me:

Einstein's Miracle Year of 1905, an amazing collection of papers on four very different topics.

Because Einstein published all four of these papers in a single year, 1905 is called his annus mirabilis (miracle year).

• The first paper explained the photoelectric effect, which established the energy of the light quanta 𝐸=ℎ𝑓, and was the only specific discovery mentioned in the citation awarding Einstein the 1921 Nobel Prize in Physics.[2]
• The second paper explained Brownian motion, which established the Einstein relation 𝐷=𝜇𝑘B𝑇 and led reluctant physicists to accept the existence of atoms.
• The third paper introduced Einstein's theory of special relativity, which used the universal constant speed of light 𝑐 to derive the Lorentz transformations.
• The fourth, a consequence of the theory of special relativity, developed the principle of mass–energy equivalence, expressed in the equation 𝐸=𝑚𝑐2 and which led to the discovery and use of atomic energy decades later.

The development of quantum theory in the early 1900s basically came out of spectroscopic observations folks were trying to explain.

The development of commercial polymers, one of the first was Nylon at duPont by a fellow named Carruthers..  He got a patent on a way to make Nylon, but missed a second way, and BASF patented the second way, and perhaps because of that Carruthers committed suicide.

The total synthesis of Vitamin B12 by Woodward, probably the first massive molecule of that complexity to be made synthetically.

Not exactly science, but Newton during a plague outbreak developed his theories and laws relating to motion, gravity, etc., and the calculus.

Great example and, once again, in Medicine.