QB/WR/TE, advantage Michigan State, and I think by a lot.
Running back is probably a toss-up. Walker I think is the best, but Michigan has the next three, and they aren't that far behind.
Offensive line is Michigan by a mile. Imo the single biggest positional advantage in the matchup.
Defensive line is also probably a toss-up, similar to running back, but flipped. Hutchinson is the best singular player, but I think MSU has more guys. And Panasiuk is leading the nation in QB pressures per PFF.
Linebacker is pretty clearly Michigan, but not by as wide a margin as o line. MSU has Halladay and nothing.
Secondaries look pretty similar to me. Both have question marks at cornerback, but pretty solid safety play.
Special teams are also pretty similar. Both teams have great punters. Both teams have potentially great kickers, but I'll give the edge to Michigan, because they have more consistency. Coghlin hit a pair of 50 yarders against Indiana, so hopefully he has turned a corner. I think he had missed every field goal from outside 40 yards prior to that this season