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Topic: CRISPR and AI

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Cincydawg

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Re: CRISPR and AI
« Reply #126 on: February 18, 2026, 11:13:45 AM »
I have pondered how well AI would do developing new chemistries.  I don't know.  It seems like a challenge, you need a degree of creativity and thought as well as core knowledge.

MikeDeTiger

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Re: CRISPR and AI
« Reply #127 on: February 18, 2026, 01:11:03 PM »
 *lots of good stuff*


One of the things that has changed is that now older AI's are taking an active role in developing newer AI's.  This has been done previously, and talked about at length with lots of projections and speculations.  I think the exponential curve of development has been understood to be a possibility for a while, and even expected.  But drawing on what you wrote, it kinda seems like now is the first time we're really starting to see it in reality.

And it's kind of like the Grand Canyon.  You can know you're going and what you'll see.  You might have seen pictures and had people tell you in detail all about it.  But when you actually get there for yourself, no matter how much you perceived it in other ways, it will take your breath away.  

bayareabadger

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Re: CRISPR and AI
« Reply #128 on: February 18, 2026, 03:27:48 PM »
This whole discussion makes me wonder what the outlook would’ve been 50 years ago, with the knowledge a huge number of American jobs would be wiped out. And also asks the question of that the future of labor will look like. 

Our society functions because we create various needs for production/labor and people meet those. In the past, when needs dried up, others replaced them. Maybe that happens again, maybe not. It’ll be strange if we end up with a small elite of employed AI engineers and a large set of the unemployable. It’ll blow up our way of life, to a degree.

I’ve been struggling with adopting in part because I have trouble with finding day-to-day uses outside of work, and the in-work ones have been somewhat limited (granted it’s going to wipe out/replace the whole field soon, probably). Hopefully I’ll pivot before then, but maybe after. Granted, the field I’m in will have basically flitted in and out of existence in about two decades, and there’ll be something else I can probably find my way into. 

Drew4UTk

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Re: CRISPR and AI
« Reply #129 on: Today at 08:07:40 AM »
the 'real', in my humble opinion, trick that makes AI work happened back around 2004 or so... some guys got together and created a means to create databases on the fly... eliminating the need for tables and queries.  those were prompted by the 'user' and in real time a database was tossed together.  

it was at this point someone realized those mountains of data being collected actually had value.  they didn't have to be cataloged and placed in rigid places that were relevant to their use/context and then cross-referenced or existing in another place altogether in another context- they could be scanned and located just once.  The adjacent words provide the relevance, pretty much just like in 'context' of writing or speaking.  So using this approach the piles and piles of data could simply rest instead of being shuffled within a massive sprawling complicated overwhelming to most computers database.... a series of tables was constructed real time and then it was tossed when done. 

maybe some of y'all recall, but i tried to install a function here, and i still have it somewhere, that makes certain words hyperlinks and to whatever item or information they were referencing.  i got the idea from an advertisement company that did almost the same- but the links (you'd get a little tool-tip over the hyperlink when you hovered with a functional screenshot of the linked page) would go to whoever the company they were contracted to advertise went to.... i tried to make this happen to feed a search function which rewarded a thread or post based on simple quantity of times a certain phrase was used.  What was discovered is the function was incredibly resource hungry and pages were disrupted with tons of little links with tool-tips... which made the page crawl, and, I couldn't seem to control how many times it would try to run- any time a mouse jiggled or a scroll happened or input into a form field was made it tried to run.  so... it hit the circular.  I mention it because- the results (not the means) isn't far from what this thing I'm speaking about does... it collects every datum and discovers it's place in context, and looks for pages/products relevant to it before shoving it through a filter and sharing it.  

imagine piles and piles and piles of piles of data collected from phones, personal computers, servers, websites, et al.  and all of the sudden being able to use it in a functional way- not just a statistical way.  the information available is at the edge of not being able to conceptualize by most people (by most people I likely mean 'me').  it is shocking, to me. 

from that came probabilities. it may have been the first version of AI.  it rapidly collected any information regarding whatever the prompt was and gave probabilities.. it spoke akin to the old google- "87.3% relative" as an example... those were quickly translated to literal probabilities- and the user of this mechanism could offer- based on presentable evidence *someone may or may not have been able to collect themselves- what the likelihood of something happening, being successful, or failing, would be.    

(* the creators and users of this thing, at first though the system had a bug when it would collect items that seemed not relative to the task, but learned that the system was capable of seeing trends and relationships they weren't- it was a 'bug' in the mind, not the machine, so to speak.)

so as the tale continues, and interjecting some wild information here:

several gov't organizations had keen interest in this.  they contracted its development to a couple companies that were literal recent start-up nobodies.  they were smart in the fact they hired the best defense contract writers- and they pulled the wool over uncle sam.  the contracts were arranged in such a way the information requested belonged to the gov't, but the mechanism didn't.  it remained property of the companies.  even though the gov't paid for the development of the system it didn't belong to them... just what came out of it and only what they requested come out of it.  the companies knew the value of this thing to advertisers. they can granularly target YOU with advertisement and have a one-shot mechanism for companies seeking to advertise.  

at any rate and cutting this off, the device described has evolved.  data can be parsed faster; it uses phrase collection and reconciles against adjacent word use which is two distinct functions happening concurrently, and now, it 'remembers' useful functions and stores them away for future usage.... almost like a script cache stores script functions so it only has to run once- logging the result and retreading it as needed, and finding new relationships along the way.  

AI isn't sentient or even singular... there is debate if that will ever be done... it's artificial.  it mimics, and that is all it'll ever be.  as it's access to data that replicates personalities is indexed over and over again, and new arrives every second (those phone carriers? they found a place to dump the data for profit- something that was a flush problem before) and makes it's rendition of what it thinks we are more and more convincing... but it can't ''think', it can just compare.  hell, there are some people like that and they certainly have their use, but..... whatever leap (and there will be one) that happens technologically has a ceiling if/when AI takes over.  it may take 100 years to get there, and it'll certainly be beyond whatever we could do on our own without that function, but it will be stymied by past.... without human interaction. ... like a great big race to get to the 23rd Century, and then? We stagnate or maybe even just disappear as a species.  

re: six fingers and seven toes.... AI is now tagging images made by AI so AI doesn't replicate or process information that is wrong without knowing it 'could be a bad source of information'.   that's kinda funny, no?     

MikeDeTiger

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Re: CRISPR and AI
« Reply #130 on: Today at 09:57:11 AM »
Data inbreeding, it's called.  It's already a problem, even while the models are still continuing to get better.  

Some of you know I have some ML background, but it's mostly confined to more analytical models.....regression, various classification algorithms, clustering....stuff like that.  I know about neural networks and LLMs, but I've never personally messed with building them.  I understand the tokenization of inputs, how the tokens are used, how the models predict the next most likely token so that we get something meaningful out of the "conversation," that type of thing.  

One thing that I still don't fully grasp which still seems like magic to me is how the model can be so compressed to something like, say, 4 TB, when it trained on, oh I don't know, however many TB it takes to holds the world's data.  It doesn't hold that data in memory, it just trained on it.  So it's not referencing training material when it generates its response.  It's just iterating through its structure, but without actually "knowing" much at all about the subject at hand.  But somehow the model can pull the next most probable word right out of its ass, and often, it makes sense.  

I mean, I get how NN's work (which is different than "understanding" them, and I'm skeptical of anybody who says they do....no you don't, nobody does.....knowing how the nodes connect does little to explain the incomprehensible combinations of ways they connect themselves in training), but the fact they can mimic holding all that data without actually holding it?  Crazy.  

on another note, to HonestBuckeye's point....I'm sort of like an auto mechanic who never learned to drive.  I know about AI, probably more than the average person, and will build analytical models if I need to, but I use generative AI very little.  Actually, several of my coworkers who don't have any idea what's under the hood in these things, use AI for all kinds of stuff around here, and easily surpass me in ideas for where to use it, best practices and best ways to prompt to get the best results, etc.  User stuff.  I guess I should try to get on that, but I have to say, I work in data management and analytics, and it's against our policy and against both state and federal law to put most of what I work with into an external AI.  Almost everything I do contains sensitive, protected data.  I'm not allowed to let AI try to help me in most things or do agent-style tasks for me, and I'd be fired if I were caught doing it.  

Cincydawg

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Re: CRISPR and AI
« Reply #131 on: Today at 10:00:53 AM »
I would be fascinated were I working now to attempt to use AI in my work.  Maybe we could ask it who will win the NC next season ....

Cincydawg

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Re: CRISPR and AI
« Reply #132 on: Today at 10:45:32 AM »
I glanced over an article about someone using AI to select stocks, maybe a mutual fund?  It wasn't going well.


utee94

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Re: CRISPR and AI
« Reply #133 on: Today at 10:49:22 AM »
I glanced over an article about someone using AI to select stocks, maybe a mutual fund?  It wasn't going well.


We use AI to forecast future demand directly, and to develop additional forecasting models to forecast future demand directly.

In both cases my own forecast beats the AI models by 20% or more on average.

On the models that I've taken time to train directly, I'm still beating them by 15% or more on average.

But I'll tell you this-- 5 years from now the AIs are going to be better than me.


Cincydawg

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Re: CRISPR and AI
« Reply #134 on: Today at 10:52:20 AM »
If AI becomes better than anything else in all prediction markets ... things will be different.  What happens to Vegas?  The stock market?

Drew4UTk

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Re: CRISPR and AI
« Reply #135 on: Today at 11:34:55 AM »
AI is like a psychologist that will tell you "the best predictor of future behavior is past behavior.".... and it's true... except for those wild cards that... well... are wild cards... they happen with such low frequency or in such timing or space they are hard to account for.... like cards being shuffled or somebody calling in sick at a job and the butterfly impact cascading downline.. AI would regard that as a statistical anomaly and be right.  but us?  we gauge everything off of a different way of processing that same dataset. rationale mixing with emotional response- or gut feelings that are really just your sub-conscious cutting to the chase. 

MikeDeTiger

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Re: CRISPR and AI
« Reply #136 on: Today at 11:38:57 AM »
Vegas would probably just change the odds.  That's the general answer to higher confidence, historically.  

The stock market is a murkier prospect.  There have been bots performing trades for years, much faster than humans can execute them, and owned by people who can afford to place them physically next to the exchange servers so that they beat literally anyone else to a buy/sell order.  And there's been massive companies for decades who effectively manipulate the market, which is technically illegal, but also inevitable when you dump or scoop up that much volume.  The conditions on which successful day-traders base their actions basically stay the same through all this, they just move to different price points as a result of the new environment.  I suspect the continued infusion of improved AI into the system will basically amount to the same thing, but I don't know.  We expect the market to go up over time, and all else being equal, I don't think that changes due to increased AI market transactions.  

I say "all else being equal" because I'm assuming a continued stable economy.  But the economy is precisely what I have no idea about in the coming AI onslaught.  

 

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