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Topic: CRISPR and AI

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betarhoalphadelta

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Re: CRISPR and AI
« Reply #70 on: January 31, 2025, 10:52:05 AM »
AGI will be able to evolve itself, and the next version will evolve itself, and so forth and so on. Once we get to that step, what comes next is really steep. I first heard about this transition, called the singularity about 10 or so years ago. At the time, most people assumed it was going to be in the 2030’s or 2040’s. Now, some people think we may be on the verge.
Yeah, the Ray Kurzweil book The Singularity Is Near was a pretty seminal work that got a lot of attention when published in 2005. He actually just released The Singularity Is Nearer last year. I've got it on my Kindle but haven't gotten around to it yet...

utee94

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Re: CRISPR and AI
« Reply #71 on: January 31, 2025, 11:12:28 AM »
I hadn't heard any talk about "the singularity" using that exact term, until the past decade or so, but apparently it's a concept/prediction that's been around since the 50s and was first suggested by a mathematician named John von Neumann.

But of course there is all sorts of hard science, and sci fi, literature and media on the subject, going back to that same period, and even before, even if it's not named in the exact same way.



betarhoalphadelta

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Re: CRISPR and AI
« Reply #72 on: January 31, 2025, 11:12:55 AM »
There's also a sci-fi series that actually has a significant amount of its story built around the relationships between biological and artificial intelligence, with a lot of characters who are self-aware digital entities (SADEs). I don't want to give too much away, but I think it does a good job of both the positive ways AI can develop and the negative. 

It starts with a book called The Silver Ships by an author named Scott Jucha. The original series plus all the spinoffs is a total of 39 books now, but they're relatively short individually and read quickly--it's not what you'd call "hard sci-fi". 

I'm not going to say it's some groundbreaking series. Some of the books can be a little formulaic. And yet... I've read them all and every time a new one is released (about every 4 months) I buy it as soon as I know it exists and typically read it pretty much cover to cover (to the extent you can do that on a Kindle lol) in a day that weekend. It's good, light, pulp sci-fi. 

CatsbyAZ

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Re: CRISPR and AI
« Reply #73 on: January 31, 2025, 11:32:33 AM »
I think of its discovery like Cristopher Columbus sailing for India. He had the technology (a ship), enough expertise, and the drive to give it a shot crossing the seas. But what was ultimately discovered was quite unexpected (the Americas). We have the technology (quickly advancing Narrow AI) and the drive (arms race) to give it a shot. We expect to discover a separate though alike consciousness, yet what we more likely stumble upon will be much more alien than we could've expected (more on all this in a later post).

I'm in the "not concerned" camp of AI and its potential to screw us over.  For what AI is and does and can be, we're irrelevant.  We're normally foolish and sometimes clever apes. 

I disagree with the "we're just an anthill in Africa and AI wouldn't think twice to destroy us" idea......I view it more as we're AI's pet golden retriever and it's fearful of us enough to try to harm us.  Nonsensical.

I don’t think we can predict what General AI, with an awareness free of its base programming (because, by definition, it reprogrammed itself), will conclude about the human species.

Going back to Philosophy, I like falling back on Hegel’s Lord–bondsman dialectic. To quote Wikipedia: “The passage describes, in narrative form, the development of self-consciousness as such in an encounter between what are thereby two distinct, self-conscious beings. The essence of the dialectic is the movement or motion of recognizing, in which the two self-consciousnesses are constituted in each being recognized as self-conscious by the other. This movement, inexorably taken to its extreme, takes the form of a "struggle to the death" in which one masters the other, only to find that such lordship makes the very recognition he had sought impossible, since the bondsman, in this state, is not free to offer it.”

In other words, two separate self-consciousness beings, once recognizing the self-consciousness of the other, seek to overcome each other. Hegel is, in highly theoretical terms, attributing the competition, rivalry, and conquering waged between human beings not first to resources, pride, or jealousy, but to an inevitably of beings to seek to overcome each other, collectively and/or individually, before anything else is at stake between each other.

We as humans have only had to face self-consciousness in other human beings; never with anything else. General AI will put us face to face with a non-human self-consciousness for the first time. In Hegel’s terms, AGI self-consciousness will seek to overcome humans once AGI recognizes that we human constitute a separate self-consciousness, regardless of not otherwise being in competition with each other over matters like resources.

And once this occurs, what will AGI conclude about humans? That we are prone to self-destructive tendencies or subject to declining health in ways that AGI is not. The worry is if an ever AGI/ASI eventually finds itself a vastly superior being to humans, we’ll be dismissed and treated as such, like termites.

utee94

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Re: CRISPR and AI
« Reply #74 on: January 31, 2025, 11:38:28 AM »
It's also possible that self-consciousness, self-awareness, sentience, simply isn't possible for an artificial intelligence.  Just as many reasons to think it might never happen, as there are to think it inevitably will happen.


betarhoalphadelta

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Re: CRISPR and AI
« Reply #75 on: January 31, 2025, 12:02:44 PM »
We as humans have only had to face self-consciousness in other human beings; never with anything else. General AI will put us face to face with a non-human self-consciousness for the first time. In Hegel’s terms, AGI self-consciousness will seek to overcome humans once AGI recognizes that we human constitute a separate self-consciousness, regardless of not otherwise being in competition with each other over matters like resources.
However to suggest that an alternative non-human self-consciousness will follow the same patterns in behavior towards other recognized self-consciousnesses as Hegel postulates about humans is, IMHO, silly.

Our experience with self-conscious species is n=1. Too small of a sample size to extrapolate to all other potential self-conscious types of entities. 

It's also possible that self-consciousness, self-awareness, sentience, simply isn't possible for an artificial intelligence.  Just as many reasons to think it might never happen, as there are to think it inevitably will happen.
It's an important point. We have no idea why we're self-aware and sentient. We don't understand it, so we may not be going down a road where it is possible to create it artificially because perhaps there are unknown inherent dependencies to get there that we aren't including in the "recipe". 

Cincydawg

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Re: CRISPR and AI
« Reply #76 on: January 31, 2025, 12:05:35 PM »
Self awareness is weird.  Je pens, donc, je suis, or something.  Cogito ergo sum etc.

Cincydawg

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Re: CRISPR and AI
« Reply #77 on: January 31, 2025, 12:25:13 PM »
One POI in "TMIsAHM" is how "Mike" became aware, and then how that ended.  How would we know if some advanced AI was "aware".  Hay, Siri, are you aware of yourself?

My wife uses Siri as a timer.  I deleted it from my phone, I'd be walking along and Siri would pipe up saying for me to repeat something, she didn't quite get it.  I got annoyed with that quickly.  I guess I "butt dialed" Siri or something.  It happened daily.

Go away, leave me the H alone.  

I'm aware of myself, the rest of youse could be figments, a bit of undigested beef etc.  

utee94

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Re: CRISPR and AI
« Reply #78 on: January 31, 2025, 01:10:44 PM »
We've focused on AI and not so much on CRISPR.  I don't have much to say about it because I really know nothing about it, but I think it was @betarhoalphadelta that raised a question about how it's possible to splice into a current, full-grown human, to potentially correct deficiencies or make repairs?  I'm not sure how that would work, either.


847badgerfan

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Re: CRISPR and AI
« Reply #79 on: January 31, 2025, 01:15:29 PM »
We've focused on AI and not so much on CRISPR.  I don't have much to say about it because I really know nothing about it, but I think it was @betarhoalphadelta that raised a question about how it's possible to splice into a current, full-grown human, to potentially correct deficiencies or make repairs?  I'm not sure how that would work, either.


You cut their chest open and have at it. Worked for me.
U RAH RAH! WIS CON SIN!

Cincydawg

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Re: CRISPR and AI
« Reply #80 on: January 31, 2025, 01:27:43 PM »
I posted some links to how it can be used on adult humans.  It's still pretty experimental.

CRISPR Advancements for Human Health - PMC

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) has emerged as a powerful gene editing technology that is revolutionizing biomedical research and clinical medicine. The CRISPR system allows scientists to rewrite the genetic code in virtually any organism. This review provides a comprehensive overview of CRISPR and its clinical applications. We first introduce the CRISPR system and explain how it works as a gene editing tool. We then highlight current and potential clinical uses of CRISPR in areas such as genetic disorders, infectious diseases, cancer, and regenerative medicine. Challenges that need to be addressed for the successful translation of CRISPR to the clinic are also discussed. Overall, CRISPR holds great promise to advance precision medicine, but ongoing research is still required to optimize delivery, efficacy, and safety.
Introduction
The CRISPR system is comprised of a CRISPR-associated (Cas) endonuclease along with a single guide RNA (sgRNA) designed to target a specific DNA sequence. Cas nucleases are enzymes that can bind and create double-stranded breaks in DNA. sgRNAs contain a scaffold structure that complexes to the Cas protein and also includes a uniquely engineered segment that can be designed to direct the Cas protein to a specific DNA sequence of interest. CRISPR technology enables precise targeting of nearly any genomic location simply by altering the nucleotide sequence of the sgRNA. This targeted approach can help to correct disease-causing mutations or suppress genes linked to the onset of diseases.1 CRISPR has been adapted for deleting gene function (knockout), adding new gene function (knock-in), activation or repression of endogenous genes, and genomic diagnostic screening techniques.
Advanced CRISPR approaches such as base editing and prime editing use modified Cas enzymes which can induce precise single nucleotide changes in the genome without creating double-strand DNA breaks.2 CRISPR can also be used to activate genes (CRISPRa) or inactivate genes (CRISPRi) by targeting modified sgRNA/Cas complexes to the gene’s promoter region, recruiting transcription factors for increased gene expression or repressors for decreasing gene expression.3
While CRISPR-Cas technology has demonstrated immense potential as a genome editing tool, its use in clinical applications is still in the early stages. As of January 2024, only 89 clinical trials employing CRISPR are currently underway, highlighting that much work remains to translate this technology into approved gene therapies.4 Notably, unintended alterations in DNA can occur through the utilization of CRISPR, and the long-term consequences of these modifications on patient health remain uncertain. However, given the considerable benefits that CRISPR offers, it is plausible to anticipate that these challenges will be overcome in the foreseeable future.



Cincydawg

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Re: CRISPR and AI
« Reply #81 on: January 31, 2025, 01:28:10 PM »

betarhoalphadelta

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Re: CRISPR and AI
« Reply #82 on: January 31, 2025, 02:52:31 PM »
CD posted those links upthread so I didn't really comment, but it cleared it up. It's not wholesale replacement of the DNA across the entire body.

There were two cases where they discussed introducing or reintroducing cells that had been edited:


  • One was some sort of a bone marrow disease. I believe they removed some bone marrow, edited the DNA so the bone marrow cells no longer had the genetic defect, then reintroduced it. Because healthy bone marrow can apparently then outcompete and grow in place of the dying bone marrow, it solved the issue. (I think this is how bone marrow transplants work--you don't have to replace all of it--it's the addition of the healthy marrow as long as its a donor match that over time replaces the bad stuff). 
  • The other was some sort of a blood / cancerous T cell issue. I think for that they had some sort of a donor, they edited the DNA so that the recipient's body wouldn't reject the new T cells, and the T cells were then able to go in and hunt down the patient's cancerous T cells and the cancer went into remission. 

There was one other case that they talked about actually introducing the DNA, which sounded familiar like I'd heard of the concept before:

  • A patient with a genetic degenerative eye disease which causes eventual blindness. Apparently for this the spliced the DNA into a virus, with the expectation that the virus would introduce the corrected DNA into the patient's cells. The virus was [to be?] injected into the eye (woo! that sounds fun!). I don't recall if that was a discussion of an actual patient case or if it was just theoretical. 

I'd heard of the concept of using a virus to introduce the changes, which is the only way IMHO that you could see a more widespread change of DNA in an extant adult person. But to me also sounds like playing with fire :smiley_confused1:


utee94

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Re: CRISPR and AI
« Reply #83 on: January 31, 2025, 02:55:32 PM »
I'd heard of the concept of using a virus to introduce the changes, which is the only way IMHO that you could see a more widespread change of DNA in an extant adult person. But to me also sounds like playing with fire :smiley_confused1:


Well, we've got to have SOMEONE to fight the AI when it attempts to overthrow us.  Might as well be the zombie mutants we accidentally created via the viral gene replacement process.

 

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