Not from here.
You said 21 hours to fly from RSW, no?
Google says 18.5 to drive:
Shared route
From Southwest Florida International Airport to Gate A via I-77 N.
18 hr 29 min (1,231 mi)
18 hr 29 min in current traffic
1. Head northeast on Terminal Access Rd toward Lower Level
2. Continue straight to stay on Terminal Access Rd
3. Use the middle lane to stay on Terminal Access Rd
4. Slight right
5. Merge onto I-75 N
6. Take exit 354 for US-27 toward Ocala/Williston
7. Use the right 2 lanes to turn right onto US-27 S/NW Blitchton Rd/Old Blitchton Rd (signs for Ocala/Silver Spgs)
8. Turn left onto NW 35th Ave Rd
9. Keep right to stay on NW 35th Ave Rd
10. Turn left onto US-301 N/US-441 N
11. Keep right to continue on US-301 N, follow signs for Starke
12. Continue straight to stay on US-301 N
13. Use the right lane to take the I-10 E ramp to Jacksonville
14. Merge onto I-10 E
15. Use the 2nd from the right lane to take exit 356 toward Int'l Airport/Savannah
16. Keep left at the fork, follow signs for Interstate 295 N/Int'l Airport/Savannah
17. Use the left lane to take exit 35B for I-95 N toward Int'l Airport/Savannah
18. Take exit 86B for I-26 W toward Columbia
19. Take exit 116 for I-77 toward Charlotte
20. Keep left to stay on I-77 N
21. Keep left to stay on I-77 N
22. Take exit 32 for I-81 N toward Roanoke
23. Keep left to stay on I-81 N, follow signs for Winchester
24. Take exit 310 for VA-37 N toward US-50 W/US-522 N/Romney/Berkeley Springs
25. Use the left 2 lanes to turn left onto VA-37 N/Virginia Rte 37 Nb N
26. Use the right lane to take the US-522 ramp to Winchester/Berkeley Springs
27. Use the left 2 lanes to turn left onto US-522 N
28. Keep left at the fork, follow signs for I-68 W/US-40 W/I-70 W/US-522 N/Cumberland/Breezewood
29. Take the US-30 E exit toward I-70 W/Harrisburg/McConnellsburg/New Stanton/Pennsylvania Turnpike
30. Use the right lane to turn right onto US-30 E
31. Use the right 2 lanes to turn slightly right onto the ramp to Harrisburg/New Stanton
32. Take the I-70/I-76 W exit toward Pittsburgh
33. Take exit 146 toward Altoona/Johnstown
34. Use any lane to turn left onto US-220 BUS N
35. Turn left onto the I-99 N/US-220 N ramp to Altoona
36. Keep right at the fork, follow signs for I-99 N/US-220 N/Altoona
37. Use the right lane to keep right at the fork and continue on US-322 E
38. Take exit 73 toward Innovation Pk/Penn State Univ
39. Keep right at the fork, follow signs for Visitor Center Tourist Info/Beaver Stadium/Bryce Jordan Ctr/Airport
40. Merge onto E Park Ave
41. Turn left onto Porter Rd
42. Arrive at location: Gate A
For the best route in current traffic visit
https://maps.app.goo.gl/gwHvzeZ28bi1hSQ86