Last time OSU was favored by 50+ was against Rutgers in 2019. They didn't cover.
The time before that was against Florida A&M, also with a backup QB (Kenny G), and they won 76-0, with Smooth Jazz tossing 6 TDs, all in the first half. Then Freshman Cardale Jones played the entire 2nd half, without throwing a single forward pass.
But it is all moot of course, as the spread for this game has now dropped below 50 at 49.